Alpha-Synuclein Mutations Mislocalize Cytoplasmic p300 Compromising Autophagy, Which Is Rescued by ACLY Inhibition

Medicine, Neurology,
Alpha-Synuclein   Autophagy   ACLY Inhibition   Parkinson's Disease   p300   mTORC1   Neuronal Models  

Academic Background Parkinson’s Disease (PD) is the second most common neurodegenerative disorder, characterized by motor dysfunction, loss of dopaminergic neurons, and abnormal accumulation of alpha-synuclein (α-syn). Although the cause of most PD cases remains unclear, approximately 5%-10% of cases are due to monogenic mutations. The SNCA gene, w...

Tetramethylpyrazine Nitrone Promotes the Clearance of Alpha‑Synuclein via Nrf2‑Mediated Ubiquitin–Proteasome System Activation

Medicine, Neurology,
Parkinson's Disease   Tetramethylpyrazine Nitrone   Peroxisome Proliferator-Activated Receptor Gamma Co-Activator 1 Alpha   Nuclear Factor Erythroid 2-Related Factor 2   Ubiquitin-Proteasome System   Alpha-Synuclein  

Tetramethylpyrazine Nitrone Promotes α-Synuclein Clearance: NRF2-Mediated UPS Activation Background Parkinson’s Disease (PD) is a common neurodegenerative disorder primarily characterized by the degeneration of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies, with α-synuclein (α-syn) aggregation as the main component. ...