Academic Background Chemical Exchange Saturation Transfer (CEST) Magnetic Resonance Imaging (MRI) is an advanced non-invasive imaging technique that provides detailed molecular information about living tissues. CEST MRI works by selectively saturating exchangeable protons of specific metabolites and transferring this saturation to water molecules, ...
Background Introduction Dementia is a global health issue that significantly impacts patients’ quality of life and places a substantial burden on healthcare systems. Alzheimer’s Disease (AD) and Frontotemporal Dementia (FTD) are two common types of dementia, and their overlapping symptoms make accurate diagnosis and targeted treatment development p...
Academic Background Electroencephalogram (EEG) is a crucial tool for studying brain activity, widely used in neuroscience, clinical diagnosis, and brain-computer interfaces. However, EEG signals are often contaminated by various artifacts during acquisition, such as electrooculography (EOG) and electromyography (EMG). These artifacts significantly ...
Academic Background Equilibrioception is a crucial ability for mammals to perceive and navigate the three-dimensional world. This ability relies on the rapid mechanoelectrical transduction (MET) response of vestibular hair cells (VHCs), which detects the position and motion of the head. Although previous studies have shown that transmembrane channe...
Background Brain tumors, particularly medulloblastoma (MB) in children, are one of the leading causes of cancer-related deaths in pediatric populations. Despite advancements in treatments such as surgical resection, radiotherapy, and chemotherapy, the prognosis for high-risk MB remains poor. In recent years, immunotherapy, especially CAR-T cell the...
Academic Background Heat Acclimation (HA) is a key adaptive response in mammals to repeated exposure to high temperatures, essential for improving cardiovascular function, thermal comfort, and exercise capacity. However, due to the lack of genetically tractable models, the molecular and neural mechanisms underlying HA have not been fully elucidated...
Academic Background Glioblastoma (GBM) is a highly malignant primary brain tumor. Despite current standard treatments such as surgical resection, radiotherapy, and chemotherapy, the prognosis remains extremely poor, with a median survival of only 14.6 months. Traditional treatments often fail to completely eradicate the tumor and are prone to recur...
Academic Background Glioblastoma (GBM) is one of the most aggressive and heterogeneous central nervous system tumors, with an extremely poor prognosis. Despite the emergence of novel therapies such as anti-angiogenic treatments and immunotherapy in recent years, the survival period of GBM patients remains very limited. GBM cells exhibit unique meta...
Background Introduction Glioblastoma (GBM) is one of the most aggressive brain cancers, with a median survival of approximately 15 months. Despite the use of multimodal treatments including surgery, chemotherapy, and radiotherapy, the overall survival rate of GBM patients has not significantly improved over the past few decades. Recent studies have...
Academic Background Glioblastoma (GBM) is the most common and aggressive primary brain tumor, with significant treatment challenges and a poor prognosis. Despite advancements in surgery, chemotherapy, and radiotherapy, the 5-year survival rate for GBM patients remains below 4%. The recurrence and therapeutic resistance of GBM are primarily attribut...