Kaposi’s sarcoma-associated herpesvirus (KSHV) is a γ-herpesvirus that primarily infects endothelial cells and leads to the development of Kaposi’s sarcoma (KS), especially in people living with HIV. Kaposi’s sarcoma is a malignant tumor characterized by endothelial cell proliferation, typically presenting as cutaneous lesions. After infecting endo...

Hypertrophic Cardiomyopathy (HCM) is a common inherited heart disease, affecting approximately 1 in 500 people globally. The primary characteristic of HCM is asymmetric hypertrophy of the myocardium. In its early stages, it may manifest as hyperdynamic contraction of the left ventricle (LV). However, as the disease progresses, patients may develop ...

Extracorporeal Membrane Oxygenation (ECMO) is a life-support technology used for patients with cardiac and respiratory failure. Although ECMO plays a crucial role in clinical practice, its use is accompanied by significant risks of medical device-associated thrombosis. Thrombosis not only obstructs blood flow in the oxygenator but also reduces gas ...

Skin wound healing is a complex biological process involving the coordination of cellular, molecular, and physiological events. Although traditional treatment methods can promote wound closure to some extent, their efficacy is often unsatisfactory in chronic wounds or complex trauma environments, particularly in controlling infections and inflammat...

Academic Background Cutaneous Squamous Cell Carcinoma (CSCC) and Basal Cell Carcinoma (BCC) are among the most common types of skin cancer globally. Although the mortality rates of these cancers are relatively low, their incidence has been increasing year by year, significantly impacting patients’ quality of life and potentially leading to prematur...

Intervertebral Disc Degeneration (IVDD) is one of the leading causes of low back pain worldwide, significantly impacting patients’ quality of life. IVDD is often accompanied by inflammatory responses, leading to the degradation of the extracellular matrix (ECM) and structural damage. Although cell therapies, such as mesenchymal stem cells (MSCs), h...

Cervical cancer and endometrial cancer are significant challenges in women’s healthcare, with high mortality rates and limited treatment options making related research particularly important. Traditional two-dimensional (2D) cell screening models can provide information on the effects of drugs on single cells but fail to capture multicellular inte...

Obesity is a growing global health issue, closely linked to metabolic diseases such as cardiovascular diseases and diabetes, as well as lymphatic dysfunction. The lymphatic system plays a crucial role in maintaining fluid balance, immune responses, and fat metabolism. However, lymphatic function is often impaired in obese patients, leading to compl...

Endothelial cells play a crucial role in the vascular system, regulating hemostasis, vasodilation, immune responses, and inflammation through intercellular junctions (IJs). However, excessive mechanical loading can lead to endothelial cell damage and endothelial barrier dysfunction. Understanding the dynamic rupture mechanisms of intercellular junc...

In recent years, autophagy, as a crucial intracellular degradation and recycling mechanism, has played a key role in maintaining cellular homeostasis and responding to various stress conditions. Particularly in renal proximal tubular epithelial cells, autophagy activity is essential for coping with common renal injuries such as ischemia, toxic dama...