Aging Promotes Reactivation of the Barr Body at Distal Chromosome Regions

1. Academic Background: The Mysterious Link between X Chromosome Inactivation and Aging In mammals, females possess two X chromosomes while males have only one. To maintain gene dosage balance between the sexes, females undergo a process called X chromosome inactivation (XCI) early in development, in which one of the two X chromosomes is randomly s...

Epigenetic Editing at Individual Age-Associated CpGs Affects the Genome-wide Epigenetic Aging Landscape

Unveiling the Mystery of the Epigenetic Aging Clock: A Review of Research on the Impact of Epigenetic Editing at Single Age-Associated CpG Sites on the Genome-wide Epigenetic Aging Landscape I. Research Background and Scientific Questions Epigenetics, especially DNA methylation, has become a cutting-edge frontier in aging mechanism research in rece...

Aberrant Engagement of P-selectin Drives Hematopoietic Stem Cell Aging in Mice

1. Research Background and Scientific Problem The health of the hematopoietic system is crucial to the proper functioning of the body, with hematopoietic stem cells (HSCs) at its core in maintaining normal blood system operation. HSCs possess self-renewal and multipotent differentiation abilities, capable of generating all types of blood cells, inc...

Gut Microbiota-Dependent Increase in Phenylacetic Acid Induces Endothelial Cell Senescence During Aging

Molecular Mechanisms of Gut Microbiota and Its Metabolites Mediating Endothelial Cell Senescence During Aging – Interpretation of Latest Results from Nature Aging I. Research Background and Significance Against the backdrop of a deeply aging human society, cardiovascular disease (CVD) has become one of the greatest health threats to the global elde...

Targeting the Chromatin Remodeler BAZ2B Mitigates Hepatic Senescence and MASH Fibrosis

1. Research Background and Significance With global population aging on the rise, the incidence of metabolic dysfunction-associated steatohepatitis (MASH, also known as NASH) and related chronic liver diseases such as hepatic fibrosis is increasing year by year. These disorders have become a major focus and challenge in basic and clinical hepatolog...

Harnessing a Noncanonical Vestibular Input in the Head-Direction Network to Rectify Age-Related Navigational Deficits

Bypassing Canonical Pathways: Uncovering a “Noncanonical” Vestibular Input for Correcting Age-Related Navigational Deficits — An Analysis of “harnessing a noncanonical vestibular input in the head-direction network to rectify age-related navigational deficits” 1. Academic Background: Why Focus on Age-Related Navigational Deficits? Spatial navigatio...

Pace of Aging Analysis of Healthspan and Lifespan in Older Adults in the US and UK

— Longitudinal Population Analysis Based on the “Pace of Aging” Method 1. Research Background and Scientific Significance With the acceleration of global population aging, objectively measuring and improving the health status of the elderly has become an important issue in social policy and public health worldwide. Traditionally, measurements of po...

Role of Recurrent Somatic Mutation and Progerin Expression in Early Vascular Aging of Chronic Kidney Disease

1. Academic Background and Research Rationale Chronic Kidney Disease (CKD) is a global public health challenge. Epidemiological data indicate that CKD affects approximately 10–12% of the world’s population, acting as a major driver of cardiovascular disease (CVD) mortality worldwide. CKD patients often display “Early Vascular Aging” (EVA) phenomena...

Quasi-spatial single-cell transcriptomics based on physical tissue properties defines early aging-associated niche in liver

Redefining the Early-Aging Microenvironment in the Liver: Quasi-spatial Single-cell Transcriptomics Reveals Fibrotic Niche Formation and Cellular Heterogeneity Background and Research Motivation Aging is an inevitable process in life, with one of its most significant features being the accumulation of senescent cells within tissues and organs. Thes...

Single-cell and spatial transcriptomics reveal divergent microenvironments and progression signatures in early- and late-onset prostate cancer

Background: Age-related Heterogeneity in Prostate Cancer and New Opportunities for Precision Medicine Prostate cancer (PCA) is the second most common malignancy and the fifth leading cause of cancer-related death among men worldwide. With the global aging population and the advancement of health screening, the age of onset for prostate cancer has b...