Mechanical Trapping of the Cell Nucleus into Microgroove Concavity but not on Convexity Induces Cell Tissue Growth and Vascular Smooth Muscle Differentiation
Academic Background Vascular Smooth Muscle Cells (VSMCs) in the normal aortic wall regulate vascular contraction and dilation. However, under pathological conditions, VSMCs transition from a contractile phenotype to a synthetic phenotype and actively participate in the remodeling of the aortic wall. Although many in vitro studies have reported the ...