Unveiling the Mystery of the Epigenetic Aging Clock: A Review of Research on the Impact of Epigenetic Editing at Single Age-Associated CpG Sites on the Genome-wide Epigenetic Aging Landscape I. Research Background and Scientific Questions Epigenetics, especially DNA methylation, has become a cutting-edge frontier in aging mechanism research in rece...
Mechanistic Study on How Retrotransposon-derived Capsid Genes PNMA1 and PNMA4 Maintain Reproductive Capacity — A New Research Review from Nature Aging I. Research Background and Scientific Significance Nearly half of the DNA in the human and mammalian genome is made up of retrotransposons, sequences that originally existed as “parasitic molecules” ...
mRNA Metabolism Regulator Human Antigen R (HuR) Regulates Age-Related Hearing Loss in Aged Mice — A Systematic Study of Molecular Pathological Mechanisms and Therapeutic Intervention 1. Academic Background and Scientific Questions Age-related hearing loss (ARHL), also known as presbycusis, is one of the most common sensory disorders in the global e...
Breakthrough Study on Consistent Self-Organized Formation of Hyaline Cartilage in hiPSC-Derived Multi-Tissue Organoids I. Academic Background 1.1 The Medical Challenge of Cartilage Injury Cartilage is an important connective tissue within human joints, with hyaline cartilage especially covering joint surfaces and playing a core role in smooth movem...
I. Academic Background and Research Significance Wound healing is a highly complex physiological process that plays a crucial role in tissue regeneration, repair, and immune regulation. However, poor healing of chronic wounds is clinically widespread, severely impacting patients’ quality of life and increasing medical and socioeconomic burdens. The...
Background Introduction Diabetes, especially type 1 diabetes (T1D), is a chronic autoimmune disease characterized by the persistent destruction of pancreatic β cells by the immune system, resulting in the loss of the ability to regulate blood glucose. Patients with type 1 diabetes typically require lifelong insulin injections; however, long-term in...
I. Academic Background and Research Motivation Atopic Dermatitis (AD) is a common chronic inflammatory skin disease characterized by eczematous lesions, intense itching, and impairment of skin barrier function. Its pathogenesis is highly complex, involving genetic susceptibility, epidermal barrier dysfunction, immune dysregulation, and environmenta...
1. Research Background and Significance Over the past decade, the role of epigenetics in regulating cell fate decisions and disease development has become increasingly prominent. As a crucial part of epigenetic regulation, modifications at the RNA level—especially N6-methyladenosine (m6A)—have been confirmed to be widely present within eukaryotic m...
Academic Background and Research Motivation In recent years, the field of stem cell and regenerative medicine has developed rapidly. Due to their multipotency and self-renewal capacity, stem cells have become a vital cell source for tissue repair and regeneration. Among the many types of stem cells, Mesenchymal Stem Cells (MSCs) have drawn consider...
Neuropeptide Substance P Regulates Stem Cell Division to Promote Wound Healing and Epidermal Stratification: An In-depth Interpretation of the Latest Study by Khalifa et al. Research Background and Scientific Questions Wound healing following skin injury has long been a central focus in both clinical and basic medical sciences. With aging, diabetes...