Facial Expressions in Mice Reveal Latent Cognitive Variables and Their Neural Correlates

Medicine, Basic Medical Sciences, Neurology, Clinical Psychology, Life Sciences, Bioengineering, Biophysics,
mouse facial expressions   latent cognitive variables   neural correlates   decision variables   motor cortex   adaptive behavior  

Revealing Latent Cognitive Variables Through Facial Expressions — In-depth Analysis of Latest Research from Nature Neuroscience Background: The Silent Dialogue Between Brain and Behavior In the fields of animal and human behavioral science, traditional theories have mainly focused on “intentional” and adaptive actions—movements that are produced to...

Augmenting AMPA Receptor Signaling After Spinal Cord Injury Increases Ependymal-Derived Neural Stem/Progenitor Cell Migration and Promotes Functional Recovery

Medicine, Basic Medical Sciences, Neurology, Neurosurgery, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
spinal cord injury   ependymal cells   neural stem cells   AMPA receptors   cell migration   functional recovery  

Enhancement of AMPA Receptor Signaling After Spinal Cord Injury Promotes Ependymal-Derived Neural Stem/Progenitor Cell Migration and Functional Recovery —— Synopsis of the Latest Research in Nature Neuroscience 1. Academic Background: Challenges in Spinal Cord Injury Repair, Potential of Ependymal Cells, and Exploration of AMPA Receptor Mechanisms ...

Embryonic Motor Neuron Programming Factors Reactivate Immature Gene Expression and Suppress ALS Pathologies in Postnatal Motor Neurons

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
motor neuron   ALS   transcription factors   gene expression   neurodegeneration   reprogramming   gene therapy  

1. Academic Background and Research Motivation Degenerative diseases of motor neurons, such as Amyotrophic Lateral Sclerosis (ALS), have long been a key research area in neuroscience. ALS is characterized by adult onset, with progressive degeneration of motor neurons leading to paralysis and death. In diseases such as ALS, aging is considered a maj...

Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
muscle-derived miR-126   TDP-43 axonal synthesis   neuromuscular junction   ALS models   neurodegeneration   local protein synthesis  

Muscle-derived miR-126 Regulates Axonal Local Synthesis of TDP-43 to Maintain Neuromuscular Junction Integrity in ALS Models — Review of a Nature Neuroscience Article I. Academic Background and Research Motivation Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset motor neuron disease, primarily characterized by neuromuscular junction (NMJ)...

Deep Representation Learning with Sample Generation and Augmented Attention Module for Imbalanced ECG Classification

Information Science, Computer Science, Artificial Intelligence, Medicine, Medical Laboratory Science, Cardiovascular System, Life Sciences, Bioengineering,
arrhythmia detection   beat classification   imbalanced learning   deep representation learning   remote health monitoring   augmented attention module   data resampling  

Innovative Application of Deep Representation Learning in Imbalanced ECG Classification —— Academic News Report on “Deep Representation Learning with Sample Generation and Augmented Attention Module for Imbalanced ECG Classification” 1. Academic Background and Research Motivation Cardiac health monitoring holds a pivotal place in modern healthcare,...

In Silico Modeling and Validation of the Effect of Calcium-Activated Potassium Current on Ventricular Repolarization in Failing Myocytes

Medicine, Basic Medical Sciences, Cardiovascular System, Life Sciences, Biochemistry, Bioengineering, Biophysics,
calcium-activated potassium channels   heart failure   ventricular repolarization   electrophysiological modeling   pharmacological modulation   arrhythmia   atrial fibrillation  

The Effect of Calcium-Activated Potassium Channels (SK Channels) on Repolarization in Failing Ventricular Myocytes—A Computational Modeling Study Research Background and Academic Significance Heart failure (HF) is a severe and prevalent cardiac disease, characterized by a comprehensive deterioration of the heart’s electrophysiological and contracti...

RDGuru: A Conversational Intelligent Agent for Rare Diseases

Information Science, Artificial Intelligence, Medicine, Pediatrics, Basic Medical Sciences, Medical Laboratory Science, Life Sciences, Bioengineering, Genetics,
rare diseases   conversational AI   deep Q-network   medical consultation   large language model   knowledge Q&A   clinical decision-making  

Intelligent Conversational Agent for Rare Diseases—RDGuru: Cutting-edge Technology Powers a New Revolution in Clinical Diagnosis Academic Background and Research Motivation Rare Diseases (RD) refer to disease categories that affect fewer than 6.5 to 10 individuals per 10,000 population. Their individual rarity, complex clinical features, and divers...