Functional Connectivity Changes in Mild Cognitive Impairment: A Meta-Analysis of M/EEG Studies

Medicine, Geriatrics, Neurology, Clinical Psychology, Medical Imaging,
Mild Cognitive Impairment   Healthy Aging   Electrophysiology   EEG   MEG   Functional Connectivity   Alzheimer’s Disease  

Changes in Functional Connectivity in Mild Cognitive Impairment: A Meta-Analysis of M/EEG Studies Background and Objectives Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss and cognitive impairment. AD is the leading cause of cognitive disorders in the elderly, accounting for approximately 60% to 80% of global c...

Chronic Evoked Seizures in Young Pre-symptomatic APP/PS1 Mice Induce Serotonin Changes and Accelerate Onset of Alzheimer’s Disease-Related Neuropathology

Medicine, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry,
Alzheimer’s Disease   Serotonin   Glia   Amyloid   Corneal Kindling   Seizures  

APP/PS1 Mouse Study Reveals Link Between Chronic Induced Epilepsy and Alzheimer’s Disease Background Alzheimer’s Disease (AD) is the most common type of dementia globally, affecting over 55 million people. The typical pathological feature of AD is the deposition of amyloid-β (Aβ) in the brain. Although Aβ deposition and the mechanisms it triggers p...

APOE4 Homozygosity Represents a Distinct Genetic Form of Alzheimer’s Disease

Medicine, Basic Medical Sciences, Neurology,
APOE4   Alzheimer’s Disease   Biomarkers   Genetic Risk   Clinical Study  

APOE4 Homozygotes Represent a Unique Genotypic Subset of Alzheimer’s Disease Introduction Alzheimer’s disease (AD) is one of the neurodegenerative diseases that modern medicine has yet to conquer, usually with a complex genetic background. While mutations in three genes (APP, PSEN1, and PSEN2) lead to early-onset autosomal dominant Alzheimer’s dise...