Chronic Toxoplasma Infection and Elevated IL-1 Lead to Hippocampal Dysfunction via DNA Double-Strand Break Signaling: A Review of the Latest Nature Neuroscience 2025 Study Academic Background and Research Rationale In recent years, neuroinflammation has garnered increasing attention in the academic community due to its role in various brain disease...
Cutting Baseline Research Report in Nature Neuroscience: Pancreas–Hippocampus Feedback Mechanism Regulates Circadian Rhythm and Depression-Related Behaviors 1. Introduction and Academic Background In recent decades, the comorbidity of neuropsychiatric disorders and metabolic dysregulation has become a research hotspot in neuroscience and psychiatri...
Introduction and Academic Background Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are two severe neurodegenerative diseases whose pathogenic mechanisms remain incompletely understood. In recent years, the RNA-binding protein TDP-43 (TAR DNA-binding protein 43) has been recognized as playing a central pathological role in bo...
Background and Motivation In the field of neuroscience, learning and memory processes rely on the intricate regulation of cellular activities in the brain. Previous research has predominantly focused on synaptic plasticity between neurons—such as long-term potentiation (LTP) and long-term depression (LTD)—as the material basis for the remodeling of...
TDP-43 Loss Induces Cryptic Polyadenylation in ALS/FTD Background Introduction Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two severe neurodegenerative diseases affecting hundreds of thousands of people worldwide. Extensive research has shown that the RNA-binding protein TDP-43 (TAR DNA-binding protein 43) displays abn...
Enhancement of AMPA Receptor Signaling After Spinal Cord Injury Promotes Ependymal-Derived Neural Stem/Progenitor Cell Migration and Functional Recovery —— Synopsis of the Latest Research in Nature Neuroscience 1. Academic Background: Challenges in Spinal Cord Injury Repair, Potential of Ependymal Cells, and Exploration of AMPA Receptor Mechanisms ...
Mechanisms of Psychedelics in Neurovascular Coupling: A Latest Research Interpretation 1. Academic Background and Research Motivation In the past decade, psychedelics such as psilocybin and lysergic acid diethylamide (LSD) have regained high attention in the scientific community due to their rapid and significant efficacy in clinical fields such as...
Nature Neuroscience Major Publication – How Leptin Receptor Neurons in the Hypothalamus Counteract Anxiety and Regulate Adaptive Behavior 1. Academic Background: The Dynamic Balance Between Anxiety and Survival Behaviors Anxiety is a protective emotional state that prevents individuals from exposure to potential danger and maintains safety. However...
1. Academic Background and Research Motivation Degenerative diseases of motor neurons, such as Amyotrophic Lateral Sclerosis (ALS), have long been a key research area in neuroscience. ALS is characterized by adult onset, with progressive degeneration of motor neurons leading to paralysis and death. In diseases such as ALS, aging is considered a maj...
Latest Nature Neuroscience Research Report: A Novel Central Mechanism of Oxytocin in Regulating Respiratory Heart Rate Variability 1. Research Background and Disciplinary Foundation Heart rate variation is an important indicator reflecting both physiological and psychological states in humans, finely regulated by the autonomic nervous system to mai...