Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation Of Histone Modifications And Gene Expression

Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation Of Histone Modifications And Gene Expression

Medicine, Oncology,
Condensate   ENL Mutation   Tumorigenesis   Histone Modifications   Gene Expression  

Scientific Paper Report: ENL Mutations Driving Tumor Development This scientific paper, written by Yiman Liu, Qinglan Li, Lele Song, et al., mainly investigates the role of ENL protein mutations in tumor development. This study was published in the 2024 issue of the journal Cancer Discovery. Background Precise control of gene expression is critical...

CRISPRi-based Circuits to Control Gene Expression in Plants

CRISPRi-based Circuits to Control Gene Expression in Plants

Life Sciences, Cell Biology, Biochemistry, Bioengineering, Botany,
Gene Editing   CRISPRi   Synthetic Biology   Logic Gates   Plant Biotechnology   Gene Expression  

Academic Background In the field of plant biotechnology, traditional gene manipulation methods focus on producing the desired phenotypes and cellular activities through continuous transgene expression. However, strong continuous promoters may lead to gene silencing, metabolic burdens, or other adverse effects on yield, preventing the full realizati...