Brain Tumors Induce Widespread Disruption of Calvarial Bone and Alteration of Skull Marrow Immune Landscape

Medicine, Basic Medical Sciences, Neurology, Neurosurgery, Hematology, Medical Imaging, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
brain tumor   calvarial bone   skull marrow   immune microenvironment   single-cell RNA sequencing   osteoclast   immune cell alteration  

A New Role for Skull Marrow Immune Microenvironment in Brain Tumors: Interpretation Based on Multicenter Studies in Mice and Humans 1. Academic Background and Research Significance Brain tumors, especially glioblastoma (GBM), are among the most aggressive malignant tumors in the central nervous system. Traditionally, they were considered localized ...

AI-Enhanced Lung Cancer Prediction: A Hybrid Model's Precision Triumph

Information Science, Computer Science, Artificial Intelligence, Medicine, Respiratory System, Medical Imaging, Oncology,
lung cancer   deep learning   convolutional neural network   bidirectional long short-term memory network   text classification   natural language processing   precision medicine  

Background Introduction Lung cancer, as one of the most prevalent and deadly malignant tumors worldwide, continues to pose many challenges in modern healthcare. According to literature statistics, the five-year survival rate for lung cancer patients is extremely low, consistently ranking it among the top three causes of cancer death globally. Due t...

WavRX: A Disease-Agnostic, Generalizable, and Privacy-Preserving Speech Health Diagnostic Model

Information Science, Computer Science, Artificial Intelligence, Medicine, Respiratory System, Environmental and Public Health, Psychiatry, Neurology, Oncology,
speech health diagnostics   disease-agnostic   privacy-preserving   generalizability   health embeddings   modulation dynamics   pathological speech  

New Breakthrough in Disease-Agnostic Remote Speech Health Diagnostic Models—An Interpretation of “wavrx: a disease-agnostic, generalizable, and privacy-preserving speech health diagnostic model” 1. Research Background and Introduction With the ongoing rise in demand for telemedicine and health management, realizing real-time, non-invasive, and auto...

Randomized Explainable Machine Learning Models for Efficient Medical Diagnosis

Information Science, Computer Science, Artificial Intelligence, Medicine, Medical Laboratory Science, Urology, Nephrology, Medical Imaging, Oncology, Cardiovascular System,
medical diagnosis   randomized models   explainable artificial intelligence   extreme learning machines   random vector functional link   big data   deep learning  

New Breakthrough in Intelligent Medical Diagnosis: Randomized Explainable Machine Learning Models Drive Efficient Medical Diagnostics I. Academic Background and Research Motivation In recent years, Deep Learning (DL) models have played a crucial role in the field of healthcare. By processing vast amounts of medical data, DL significantly improves t...

Single-cell and spatial transcriptomics reveal divergent microenvironments and progression signatures in early- and late-onset prostate cancer

Medicine, Basic Medical Sciences, Geriatrics, Urology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
single-cell sequencing   spatial transcriptomics   prostate cancer   heterogeneity   tumor microenvironment   androgen response   tumor progression  

Background: Age-related Heterogeneity in Prostate Cancer and New Opportunities for Precision Medicine Prostate cancer (PCA) is the second most common malignancy and the fifth leading cause of cancer-related death among men worldwide. With the global aging population and the advancement of health screening, the age of onset for prostate cancer has b...

Cellular Therapies for the Prevention and Treatment of Acute Graft-versus-Host Disease

Medicine, Rheumatology and Immunology, Hematology, Oncology, Life Sciences, Cell Biology, Immunology,
acute graft-versus-host disease   allogeneic hematopoietic cell transplantation   cellular therapy   T-cell depletion   mesenchymal stem cells   regulatory T cells   immunomodulation  

Advances in Cellular Therapies for the Prevention and Treatment of Acute Graft-versus-Host Disease (aGVHD) — An Authoritative Review on the Paper “Cellular therapies for the prevention and treatment of acute graft-versus-host disease” 1. Academic Background and Motivation Acute graft-versus-host disease (aGVHD) is one of the most severe complicatio...