CRISPR-dCas9 Activation of TSG-6 in MSCs Modulates the Cargo of MSC-Derived Extracellular Vesicles and Attenuates Inflammatory Responses in Human Intervertebral Disc Cells In Vitro

Medicine, Rheumatology and Immunology, Orthopedics, Life Sciences, Cell Biology, Immunology,
CRISPR-dCas9   TSG-6   Mesenchymal Stem Cells   Extracellular Vesicles   Intervertebral Disc Cells   Inflammatory Responses   Genomic Engineering  

Intervertebral Disc Degeneration (IVDD) is one of the leading causes of low back pain worldwide, significantly impacting patients’ quality of life. IVDD is often accompanied by inflammatory responses, leading to the degradation of the extracellular matrix (ECM) and structural damage. Although cell therapies, such as mesenchymal stem cells (MSCs), h...