Toxoplasma gondii Infection and Chronic IL-1 Elevation Drive Hippocampal DNA Double-Strand Break Signaling, Leading to Cognitive Deficits

Medicine, Infectious Diseases, Rheumatology and Immunology, Basic Medical Sciences, Psychiatry, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics, Microbiology,
Toxoplasma gondii infection   chronic inflammation   IL-1   hippocampus   DNA double-strand break   cognitive deficit   spatial memory  

Chronic Toxoplasma Infection and Elevated IL-1 Lead to Hippocampal Dysfunction via DNA Double-Strand Break Signaling: A Review of the Latest Nature Neuroscience 2025 Study Academic Background and Research Rationale In recent years, neuroinflammation has garnered increasing attention in the academic community due to its role in various brain disease...

Aging Promotes Reactivation of the Barr Body at Distal Chromosome Regions

Medicine, Rheumatology and Immunology, Obstetrics and Gynecology, Geriatrics, Neurology, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
aging   Barr body   X chromosome inactivation   escape genes   chromatin accessibility   sex differences   epigenetics  

1. Academic Background: The Mysterious Link between X Chromosome Inactivation and Aging In mammals, females possess two X chromosomes while males have only one. To maintain gene dosage balance between the sexes, females undergo a process called X chromosome inactivation (XCI) early in development, in which one of the two X chromosomes is randomly s...

Exosomes Derived from Exercise-Trained Mice Bone Marrow Mesenchymal Stem Cells Improve Wound Healing by Inhibiting Macrophage M1 Polarization

Medicine, Rheumatology and Immunology, Oral Sciences, Sports Medicine, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
bone marrow mesenchymal stem cells   exosome   treadmill exercise   macrophage polarization   M1   wound healing   inflammation  

I. Academic Background and Research Significance Wound healing is a highly complex physiological process that plays a crucial role in tissue regeneration, repair, and immune regulation. However, poor healing of chronic wounds is clinically widespread, severely impacting patients’ quality of life and increasing medical and socioeconomic burdens. The...

Neural Stem Cell-Derived Extracellular Vesicles Alleviate Inflammatory Responses in a Mouse Model of Atopic Dermatitis

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
neural stem cells   extracellular vesicles   atopic dermatitis   inflammation   skin barrier   immune regulation   mouse model  

I. Academic Background and Research Motivation Atopic Dermatitis (AD) is a common chronic inflammatory skin disease characterized by eczematous lesions, intense itching, and impairment of skin barrier function. Its pathogenesis is highly complex, involving genetic susceptibility, epidermal barrier dysfunction, immune dysregulation, and environmenta...

Cellular Therapies for the Prevention and Treatment of Acute Graft-versus-Host Disease

Medicine, Rheumatology and Immunology, Hematology, Oncology, Life Sciences, Cell Biology, Immunology,
acute graft-versus-host disease   allogeneic hematopoietic cell transplantation   cellular therapy   T-cell depletion   mesenchymal stem cells   regulatory T cells   immunomodulation  

Advances in Cellular Therapies for the Prevention and Treatment of Acute Graft-versus-Host Disease (aGVHD) — An Authoritative Review on the Paper “Cellular therapies for the prevention and treatment of acute graft-versus-host disease” 1. Academic Background and Motivation Acute graft-versus-host disease (aGVHD) is one of the most severe complicatio...

Alzheimer’s Disease and Age-Related Macular Degeneration: Shared and Distinct Immune Mechanisms

Medicine, Rheumatology and Immunology, Neurology, Ophthalmology, Life Sciences, Immunology,
Alzheimer's Disease   Age-Related Macular Degeneration   Immune Mechanisms   Neuroinflammation   Therapeutic Strategies  

Academic Background Alzheimer’s disease (AD) and age-related macular degeneration (AMD) are the leading causes of cognitive impairment and vision loss in the elderly population worldwide. Although they affect different organs (the brain and the retina, respectively), recent studies have revealed shared pathological features, such as β-amyloid (Aβ) ...