Toxoplasma gondii Infection and Chronic IL-1 Elevation Drive Hippocampal DNA Double-Strand Break Signaling, Leading to Cognitive Deficits

Medicine, Infectious Diseases, Rheumatology and Immunology, Basic Medical Sciences, Psychiatry, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics, Microbiology,
Toxoplasma gondii infection   chronic inflammation   IL-1   hippocampus   DNA double-strand break   cognitive deficit   spatial memory  

Chronic Toxoplasma Infection and Elevated IL-1 Lead to Hippocampal Dysfunction via DNA Double-Strand Break Signaling: A Review of the Latest Nature Neuroscience 2025 Study Academic Background and Research Rationale In recent years, neuroinflammation has garnered increasing attention in the academic community due to its role in various brain disease...

C9orf72 Hexanucleotide Repeat Expansions Impair Microglial Response in ALS

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
C9orf72   hexanucleotide repeat expansion   microglia   amyotrophic lateral sclerosis   single-nuclei transcriptome   endolysosomal pathway   genetic mechanism  

C9orf72 Hexanucleotide Repeat Expansions Impair Microglial Response in ALS Patients — In-depth Report on the November 2025 Issue of Nature Neuroscience 1. Academic Background and Research Motivation Amyotrophic lateral sclerosis (ALS) is a disabling neurodegenerative disease characterized by progressive loss of motor neurons, with most patients dyi...

Brain Tumors Induce Widespread Disruption of Calvarial Bone and Alteration of Skull Marrow Immune Landscape

Medicine, Basic Medical Sciences, Neurology, Neurosurgery, Hematology, Medical Imaging, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
brain tumor   calvarial bone   skull marrow   immune microenvironment   single-cell RNA sequencing   osteoclast   immune cell alteration  

A New Role for Skull Marrow Immune Microenvironment in Brain Tumors: Interpretation Based on Multicenter Studies in Mice and Humans 1. Academic Background and Research Significance Brain tumors, especially glioblastoma (GBM), are among the most aggressive malignant tumors in the central nervous system. Traditionally, they were considered localized ...

Aging Promotes Reactivation of the Barr Body at Distal Chromosome Regions

Medicine, Rheumatology and Immunology, Obstetrics and Gynecology, Geriatrics, Neurology, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
aging   Barr body   X chromosome inactivation   escape genes   chromatin accessibility   sex differences   epigenetics  

1. Academic Background: The Mysterious Link between X Chromosome Inactivation and Aging In mammals, females possess two X chromosomes while males have only one. To maintain gene dosage balance between the sexes, females undergo a process called X chromosome inactivation (XCI) early in development, in which one of the two X chromosomes is randomly s...

Aberrant Engagement of P-selectin Drives Hematopoietic Stem Cell Aging in Mice

Medicine, Basic Medical Sciences, Geriatrics, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology,
P-selectin   hematopoietic stem cells   aging   gene expression   erythropoiesis   inflammation   stem cell regeneration  

1. Research Background and Scientific Problem The health of the hematopoietic system is crucial to the proper functioning of the body, with hematopoietic stem cells (HSCs) at its core in maintaining normal blood system operation. HSCs possess self-renewal and multipotent differentiation abilities, capable of generating all types of blood cells, inc...

Quasi-spatial single-cell transcriptomics based on physical tissue properties defines early aging-associated niche in liver

Medicine, Hepatobiliary System, Basic Medical Sciences, Geriatrics, Life Sciences, Cell Biology, Biochemistry, Immunology,
single-cell sequencing   fibrotic niche   liver aging   senescent cells   spatial omics   physical tissue properties  

Redefining the Early-Aging Microenvironment in the Liver: Quasi-spatial Single-cell Transcriptomics Reveals Fibrotic Niche Formation and Cellular Heterogeneity Background and Research Motivation Aging is an inevitable process in life, with one of its most significant features being the accumulation of senescent cells within tissues and organs. Thes...

Single-cell and spatial transcriptomics reveal divergent microenvironments and progression signatures in early- and late-onset prostate cancer

Medicine, Basic Medical Sciences, Geriatrics, Urology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
single-cell sequencing   spatial transcriptomics   prostate cancer   heterogeneity   tumor microenvironment   androgen response   tumor progression  

Background: Age-related Heterogeneity in Prostate Cancer and New Opportunities for Precision Medicine Prostate cancer (PCA) is the second most common malignancy and the fifth leading cause of cancer-related death among men worldwide. With the global aging population and the advancement of health screening, the age of onset for prostate cancer has b...