Tumor heterogeneity is a critical issue in cancer research, encompassing genetic, phenotypic, and microenvironmental heterogeneity. Although single-cell sequencing has shed light on genetic and phenotypic heterogeneity, the study of non-genetic factors, such as microenvironmental heterogeneity, remains insufficient. Oxidative stress is a hallmark o...

The Role of PFKFB3 in EGFR-TKIs Tolerance in Non-Small Cell Lung Cancer Background Introduction Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related deaths worldwide. Epidermal growth factor receptor (EGFR) mutations are relatively common in NSCLC, accounting for approximately 15-30% of cases. Although EGFR tyrosine kin...