Astrocytic Ca2+ Prevents Synaptic Depotentiation by Limiting Repetitive Activity in Dendrites During Motor Learning

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Biophysics,
astrocytes   synaptic plasticity   Ca2+ signaling   motor learning   dendritic activity   memory formation  

Background and Motivation In the field of neuroscience, learning and memory processes rely on the intricate regulation of cellular activities in the brain. Previous research has predominantly focused on synaptic plasticity between neurons—such as long-term potentiation (LTP) and long-term depression (LTD)—as the material basis for the remodeling of...

Distal Tuft Dendrites Predict Properties of New Hippocampal Place Fields

Medicine, Neurology,
distal tuft dendrites   hippocampal place fields   dendritic activity   spatial learning   neuronal plasticity  

Academic Background The hippocampus is a critical region in the brain responsible for spatial navigation and episodic memory. Pyramidal neurons in the CA1 region of the hippocampus (CA1 pyramidal neurons, CA1PNs) encode an animal’s position in the environment by forming “place fields” (PFs). The formation of place fields relies on behavioral timesc...