Amortized Template Matching of Molecular Conformations from Cryoelectron Microscopy Images Using Simulation-Based Inference

Information Science, Artificial Intelligence, Medicine, Medical Imaging, Life Sciences, Cell Biology, Biochemistry, Biophysics,
cryo-EM   biophysics   Bayesian inference   molecular modeling   template matching   deep learning   structural biology  

Accelerating Single-Molecule Structure Identification with Simulation-Based Inference — Research Report on “Amortized Template Matching of Molecular Conformations from Cryoelectron Microscopy Images using Simulation-Based Inference” Research Background and Significance In the fields of molecular biology and structural biology, understanding how bio...

In Situ Architecture of the Human Prohibitin Complex

Life Sciences, Cell Biology, Biophysics,
prohibitin complex   mitochondrial inner membrane   structural biology   cryo-electron tomography   molecular modeling  

Academic Background Mitochondria are the energy factories of cells, and the integrity of the mitochondrial inner membrane (MIM) is crucial for cellular function. Prohibitin (PHB) is a highly conserved protein family, consisting of two subtypes, PHB1 and PHB2, which play important roles in various cellular processes, including mitochondrial stress s...