A Quantitative Ultrastructural Timeline of Nuclear Autophagy Reveals a Role for Dynamin-like Protein 1 at the Nuclear Envelope

Background Introduction The nuclear envelope (NE) is a critical barrier between the nucleus and the cytoplasm, responsible for maintaining the stability of the nuclear environment. The integrity of the nuclear envelope is essential for normal cellular function, and its disruption is closely linked to aging and various diseases. Autophagy is a vital...

Distinct Ultrastructural Phenotypes of Glial and Neuronal Alpha-Synuclein Inclusions in Multiple System Atrophy

Different Ultrastructural Phenotypes of α-Synuclein Inclusions in Glia and Neurons in Brain Regions of Multiple System Atrophy (MSA) Introduction Multiple System Atrophy (MSA) is a severe neurodegenerative disease characterized by abnormal accumulation of α-Synuclein (α-Syn) in specific brain regions, forming pathological inclusions that primarily ...