A lateral hypothalamic neuronal population expressing leptin receptors counteracts anxiety to enable adaptive behavioral responses

Medicine, Psychiatry, Endocrinology, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
lateral hypothalamus   leptin receptors   anxiety   adaptive behavior   neurons   exploration   eating disorders  

Nature Neuroscience Major Publication – How Leptin Receptor Neurons in the Hypothalamus Counteract Anxiety and Regulate Adaptive Behavior 1. Academic Background: The Dynamic Balance Between Anxiety and Survival Behaviors Anxiety is a protective emotional state that prevents individuals from exposure to potential danger and maintains safety. However...

Dopamine Receptors D1, D2, and D4 Modulate Electrical Synapses and Excitability in the Thalamic Reticular Nucleus

Medicine, Neurology, Life Sciences,
dopamine   electrical synapses   thalamic reticular nucleus   excitability   neurons   signal transduction   receptor subtypes  

Modulation of Electrical Synapses and Excitability by Dopamine Receptors in the Thalamic Reticular Nucleus Academic Background The Thalamic Reticular Nucleus (TRN) is a thin shell of γ-aminobutyric acid (GABA)ergic inhibitory neurons in the thalamus. These neurons are coupled via gap junctions and regulate the transmission of sensory information fr...

Increased Robustness and Adaptation to Simultaneous Temperature and Elevated Extracellular Potassium in the Pyloric Rhythm of the Crab, Cancer Borealis

Medicine, Neurology, Life Sciences,
crab   pyloric rhythm   high temperature   elevated potassium   adaptation   robustness   neurons  

Increased Robustness and Adaptation of the Crab Pyloric Rhythm to Simultaneous Temperature and Elevated Extracellular Potassium Academic Background In nature, animals often face multiple simultaneous environmental perturbations, which may include temperature fluctuations, pH variations, salinity changes, and alterations in extracellular potassium c...

Network-Wide Risk Convergence in Gene Co-Expression Identifies Reproducible Genetic Hubs of Schizophrenia Risk

Medicine, Psychiatry, Life Sciences, Biochemistry, Genetics,
gene co-expression   schizophrenia   genetic risk   neurons   GWAS   genome-wide association  

The Genetic Network Aggregation Mechanism for Schizophrenia Risk — Latest Research Interpretation from the Journal “Neuron” In recent years, genetic research on schizophrenia (SCZ) has made significant progress, particularly driven by genome-wide association studies (GWAS), revealing a large number of genetic variants associated with the disease. H...

Integration and Competition Between Space and Time in the Hippocampus

Medicine, Neurology, Life Sciences, Biochemistry, Biophysics,
hippocampus   space   time   neurons   memory  

A Review on the Mechanisms of Spatial and Temporal Integration and Competition in the Hippocampus Research Background and Significance In the human and animal brain, space and time comprise the primary dimensions of episodic memory, playing a crucial role in encoding information such as event sequences, locations, and durations. It has long been fo...

Single-Nucleus Sequencing Reveals Enriched Expression of Genetic Risk Factors in ALS-Sensitive Neurons

Medicine, Basic Medical Sciences, Geriatrics, Neurology, Life Sciences, Biochemistry, Genetics,
single-nucleus sequencing   ALS   neurons   genetic risk factors   transcriptomics  

Publication of a New Study on ALS Neurodegeneration in 《Nature Aging》 Throughout human history, numerous mysterious diseases have posed significant challenges for scientific research. Among these, Amyotrophic Lateral Sclerosis (ALS), a progressive neurodegenerative disease, is known for the gradual loss of muscle function and disability it causes. ...