Vaccination of Nonhuman Primates Elicits a Broadly Neutralizing Antibody Lineage Targeting a Quaternary Epitope on the HIV-1 Env Trimer

Medicine, Infectious Diseases, Life Sciences, Cell Biology, Biochemistry, Immunology, Microbiology,
Nonhuman Primates   HIV-1 Env Trimer   Broadly Neutralizing Antibodies   Quaternary Epitope   Vaccination  

1. Research Background The envelope glycoprotein (Env) of human immunodeficiency virus type 1 (HIV-1) is the primary target of neutralizing antibodies, but its high variability poses challenges for vaccine development. Broadly neutralizing antibodies (bnAbs) are rare in natural infections and typically require years to emerge. Although Env trimer m...