Toxoplasma gondii Infection and Chronic IL-1 Elevation Drive Hippocampal DNA Double-Strand Break Signaling, Leading to Cognitive Deficits

Chronic Toxoplasma Infection and Elevated IL-1 Lead to Hippocampal Dysfunction via DNA Double-Strand Break Signaling: A Review of the Latest Nature Neuroscience 2025 Study Academic Background and Research Rationale In recent years, neuroinflammation has garnered increasing attention in the academic community due to its role in various brain disease...

Gut Microbiota-Dependent Increase in Phenylacetic Acid Induces Endothelial Cell Senescence During Aging

Molecular Mechanisms of Gut Microbiota and Its Metabolites Mediating Endothelial Cell Senescence During Aging – Interpretation of Latest Results from Nature Aging I. Research Background and Significance Against the backdrop of a deeply aging human society, cardiovascular disease (CVD) has become one of the greatest health threats to the global elde...

A self-assembling surface layer flattens the cytokinetic furrow to aid cell division in an archaeon

1. Academic Background Since the origin of life, living organisms have needed to construct effective barriers to protect their cells from external physical and chemical damage. In the realms of bacteria and archaea, the surface layer (S-layer) is a universally present and exquisitely structured two-dimensional protein lattice that substitutes for t...

Intermediate Light Adaptation Induces Oscillatory Phototaxis Switching and Pattern Formation in Chlamydomonas

Light Adaptation Drives New Motility Patterns in Green Algae — A Review of “Intermediate light adaptation induces oscillatory phototaxis switching and pattern formation in Chlamydomonas” 1. Research Background and Scientific Questions Microswimmers at the microscopic scale, such as unicellular algae, bacteria, and sperm, are important ecological co...

Intermediate Light Adaptation Induces Oscillatory Phototaxis Switching and Pattern Formation in Chlamydomonas

New Discovery of Green Microswimmer: Oscillatory Phototaxis and Pattern Formation Induced by Light Adaptation — Review of “intermediate light adaptation induces oscillatory phototaxis switching and pattern formation in chlamydomonas” 1. Research and Academic Background Light, as a core environmental signal for living organisms, drives diverse behav...

IL-10 Sensing by Lung Interstitial Macrophages Prevents Bacterial Dysbiosis-Driven Pulmonary Inflammation and Maintains Immune Homeostasis

1. Research Background The pathogenesis of chronic lung inflammation and pulmonary fibrosis remains unclear, particularly regarding the interaction between pulmonary commensal microbiota and the immune system. While interleukin-10 (IL-10), a key anti-inflammatory cytokine, has been extensively studied in gut homeostasis, its role in pulmonary immun...