Academic Background Introduction The spliceosome is a highly dynamic macromolecular complex responsible for the precise excision of introns from pre-mRNA. Although recent advances in cryo-electron microscopy (cryo-EM) have provided a comprehensive structural understanding of the stepwise assembly, catalytic splicing, and final disassembly of the sp...

Critical and Differential Roles of eIF4A1 and eIF4A2 in B-Cell Development and Function Academic Background In mammalian cells, translation initiation is a crucial step in protein synthesis, where the eukaryotic initiation factor 4A (eIF4A) plays a pivotal role. eIF4A is an ATP-dependent RNA helicase that unwinds secondary structures in the 5’ untr...