1. Academic Background: The Mysterious Link between X Chromosome Inactivation and Aging In mammals, females possess two X chromosomes while males have only one. To maintain gene dosage balance between the sexes, females undergo a process called X chromosome inactivation (XCI) early in development, in which one of the two X chromosomes is randomly s...

Unveiling the Mystery of the Epigenetic Aging Clock: A Review of Research on the Impact of Epigenetic Editing at Single Age-Associated CpG Sites on the Genome-wide Epigenetic Aging Landscape I. Research Background and Scientific Questions Epigenetics, especially DNA methylation, has become a cutting-edge frontier in aging mechanism research in rece...

1. Research Background and Significance With global population aging on the rise, the incidence of metabolic dysfunction-associated steatohepatitis (MASH, also known as NASH) and related chronic liver diseases such as hepatic fibrosis is increasing year by year. These disorders have become a major focus and challenge in basic and clinical hepatolog...

— Longitudinal Population Analysis Based on the “Pace of Aging” Method 1. Research Background and Scientific Significance With the acceleration of global population aging, objectively measuring and improving the health status of the elderly has become an important issue in social policy and public health worldwide. Traditionally, measurements of po...

1. Academic Background and Research Rationale Chronic Kidney Disease (CKD) is a global public health challenge. Epidemiological data indicate that CKD affects approximately 10–12% of the world’s population, acting as a major driver of cardiovascular disease (CVD) mortality worldwide. CKD patients often display “Early Vascular Aging” (EVA) phenomena...

1. Research Background and Academic Significance Alzheimer’s Disease (AD) is the most common form of dementia worldwide, accounting for about 60–80% of all dementia cases. The primary affected population is individuals over 65 years old, with characteristic pathological features including the deposition of amyloid-β plaques, neurofibrillary tangles...

Mitochondria-Enriched Hematopoietic Stem Cells Reveal Enhanced Self-Renewal Activity in Aged Bone Marrow: In-Depth Analysis of the Latest Study in Nature Aging I. Academic Background and Research Significance Hematopoietic stem cells (HSCs) are the essential foundation underlying life-long production of blood and immune cells. However, with aging, ...

Mechanistic Study on How Retrotransposon-derived Capsid Genes PNMA1 and PNMA4 Maintain Reproductive Capacity — A New Research Review from Nature Aging I. Research Background and Scientific Significance Nearly half of the DNA in the human and mammalian genome is made up of retrotransposons, sequences that originally existed as “parasitic molecules” ...

Analysis of Large-Scale Network Study of the CSF Proteome in FTLD — Unlocking Molecular Signatures of Neurodegenerative Diseases I. Academic Background and Motivation Frontotemporal Lobar Degeneration (FTLD) is one of the most common causes of early-onset dementia (under age 65), triggering a range of progressive behavioral, language, and even moto...

mRNA Metabolism Regulator Human Antigen R (HuR) Regulates Age-Related Hearing Loss in Aged Mice — A Systematic Study of Molecular Pathological Mechanisms and Therapeutic Intervention 1. Academic Background and Scientific Questions Age-related hearing loss (ARHL), also known as presbycusis, is one of the most common sensory disorders in the global e...