Chronic Toxoplasma Infection and Elevated IL-1 Lead to Hippocampal Dysfunction via DNA Double-Strand Break Signaling: A Review of the Latest Nature Neuroscience 2025 Study Academic Background and Research Rationale In recent years, neuroinflammation has garnered increasing attention in the academic community due to its role in various brain disease...

Cutting Baseline Research Report in Nature Neuroscience: Pancreas–Hippocampus Feedback Mechanism Regulates Circadian Rhythm and Depression-Related Behaviors 1. Introduction and Academic Background In recent decades, the comorbidity of neuropsychiatric disorders and metabolic dysregulation has become a research hotspot in neuroscience and psychiatri...

Introduction and Academic Background Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are two severe neurodegenerative diseases whose pathogenic mechanisms remain incompletely understood. In recent years, the RNA-binding protein TDP-43 (TAR DNA-binding protein 43) has been recognized as playing a central pathological role in bo...

TDP-43 Loss Induces Cryptic Polyadenylation in ALS/FTD Background Introduction Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two severe neurodegenerative diseases affecting hundreds of thousands of people worldwide. Extensive research has shown that the RNA-binding protein TDP-43 (TAR DNA-binding protein 43) displays abn...

Nature Neuroscience Major Publication – How Leptin Receptor Neurons in the Hypothalamus Counteract Anxiety and Regulate Adaptive Behavior 1. Academic Background: The Dynamic Balance Between Anxiety and Survival Behaviors Anxiety is a protective emotional state that prevents individuals from exposure to potential danger and maintains safety. However...

1. Academic Background and Research Motivation Degenerative diseases of motor neurons, such as Amyotrophic Lateral Sclerosis (ALS), have long been a key research area in neuroscience. ALS is characterized by adult onset, with progressive degeneration of motor neurons leading to paralysis and death. In diseases such as ALS, aging is considered a maj...

Muscle-derived miR-126 Regulates Axonal Local Synthesis of TDP-43 to Maintain Neuromuscular Junction Integrity in ALS Models — Review of a Nature Neuroscience Article I. Academic Background and Research Motivation Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset motor neuron disease, primarily characterized by neuromuscular junction (NMJ)...

C9orf72 Hexanucleotide Repeat Expansions Impair Microglial Response in ALS Patients — In-depth Report on the November 2025 Issue of Nature Neuroscience 1. Academic Background and Research Motivation Amyotrophic lateral sclerosis (ALS) is a disabling neurodegenerative disease characterized by progressive loss of motor neurons, with most patients dyi...

New Pathway for ALS/FTD-Related C9orf72 Pathogenesis Revealed by Latest Nature Neuroscience Study Academic Background and Research Motivation Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are among the most challenging neurodegenerative diseases in clinical medicine, with complex pathogenesis that remains insufficiently expl...

Intelligent Conversational Agent for Rare Diseases—RDGuru: Cutting-edge Technology Powers a New Revolution in Clinical Diagnosis Academic Background and Research Motivation Rare Diseases (RD) refer to disease categories that affect fewer than 6.5 to 10 individuals per 10,000 population. Their individual rarity, complex clinical features, and divers...