Single-cell RNA Sequencing of Peripheral Blood Links Cell-Type-Specific Regulation of Splicing to Autoimmune and Inflammatory Diseases

Medicine, Rheumatology and Immunology, Life Sciences, Immunology, Genetics,
Single-cell RNA sequencing   Splicing regulation   Autoimmune diseases   Inflammatory diseases   Cell-type specificity   Genetic diversity   Asian Immune Diversity Atlas  

Single-cell RNA Sequencing Reveals Cell-type-specific Splicing Regulation in Peripheral Blood Linked to Autoimmune and Inflammatory Diseases Background In recent years, rapid advancements in genomics research have provided deeper insights into the genetic basis of complex traits. However, the functional mechanisms underlying most disease-associated...

Predicting Outcomes in Esophageal Squamous Cell Carcinoma Using scRNA-seq and Bulk RNA-seq: A Model Development and Validation Study

Medicine, Oncology, Life Sciences, Cell Biology, Immunology,
Esophageal squamous cell carcinoma   Glucose metabolism   Immune infiltration   Prognosis   Single-cell RNA sequencing   Bulk RNA sequencing   Bioinformatics  

Prognostic Prediction Model for Esophageal Squamous Cell Carcinoma Based on Single-Cell RNA Sequencing and Bulk RNA Sequencing Research Background Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant tumors globally, particularly prevalent in East Asia. Despite existing treatment methods such as surgery, endoscopic resectio...

Single-Cell Analysis Reveals Alterations Between the Aged and Young Mice Prostates

Medicine, Urology, Life Sciences, Cell Biology, Immunology,
Single-cell RNA sequencing   Prostate aging   Cellular heterogeneity   Gene expression   Mouse model  

Single-Cell Analysis Reveals Differences Between Aged and Young Mouse Prostates Academic Background The prostate is a vital component of the male reproductive system. As men age, the prostate undergoes hyperplasia, which can lead to urethral compression, resulting in voiding dysfunction and associated symptoms, as well as an increased risk of prost...