Randomized Explainable Machine Learning Models for Efficient Medical Diagnosis

Information Science, Computer Science, Artificial Intelligence, Medicine, Medical Laboratory Science, Urology, Nephrology, Medical Imaging, Oncology, Cardiovascular System,
medical diagnosis   randomized models   explainable artificial intelligence   extreme learning machines   random vector functional link   big data   deep learning  

New Breakthrough in Intelligent Medical Diagnosis: Randomized Explainable Machine Learning Models Drive Efficient Medical Diagnostics I. Academic Background and Research Motivation In recent years, Deep Learning (DL) models have played a crucial role in the field of healthcare. By processing vast amounts of medical data, DL significantly improves t...

Single-cell and spatial transcriptomics reveal divergent microenvironments and progression signatures in early- and late-onset prostate cancer

Medicine, Basic Medical Sciences, Geriatrics, Urology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
single-cell sequencing   spatial transcriptomics   prostate cancer   heterogeneity   tumor microenvironment   androgen response   tumor progression  

Background: Age-related Heterogeneity in Prostate Cancer and New Opportunities for Precision Medicine Prostate cancer (PCA) is the second most common malignancy and the fifth leading cause of cancer-related death among men worldwide. With the global aging population and the advancement of health screening, the age of onset for prostate cancer has b...

Hyperosmotic Stress Promotes the Nuclear Translocation of TFEB in Tubular Epithelial Cells Depending on Intracellular Ca2+ Signals via TRPML Channels

Medicine, Urology, Nephrology, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
Hyperosmolarity   Transcription Factor EB (TFEB)   Calcineurin   TRPML1   Tubular Epithelial Cell  

In recent years, autophagy, as a crucial intracellular degradation and recycling mechanism, has played a key role in maintaining cellular homeostasis and responding to various stress conditions. Particularly in renal proximal tubular epithelial cells, autophagy activity is essential for coping with common renal injuries such as ischemia, toxic dama...

Targeting ADAR1 with a Small Molecule for the Treatment of Prostate Cancer

Chemistry, Medicinal Chemistry, Medicine, Urology, Pharmacy, Oncology,
prostate cancer   ADAR1   small molecule inhibitor   tumor immunity   RNA editing  

Academic Background Prostate cancer (PCA) is one of the most common malignancies in men, particularly in Western countries, where it is the second leading cause of cancer-related deaths among males. Although androgen signaling therapy is effective in the initial treatment of prostate cancer, most patients eventually relapse, and there is currently ...

Neoadjuvant Cabozantinib for Locally Advanced Nonmetastatic Clear Cell Renal Cell Carcinoma: A Phase 2 Trial

Medicine, Urology, Nephrology, Oncology, Life Sciences, Immunology,
renal cell carcinoma   cabozantinib   neoadjuvant therapy   locally advanced   clinical trial  

Academic Background Renal Cell Carcinoma (RCC) is one of the cancers with a rapidly rising incidence globally, particularly among young patients and minorities. In the United States, an estimated 81,610 new cases of RCC will be diagnosed in 2024, with approximately 30% progressing to metastatic RCC. For locally advanced RCC, the initial treatment i...