Modulation of Bone Marrow Haematopoietic Stem Cell Activity as a Therapeutic Strategy After Myocardial Infarction: A Preclinical Study

Medicine, Hematology, Cardiovascular System, Life Sciences, Cell Biology, Immunology,
myocardial infarction   bone marrow haematopoietic stem cells   inflammation   vitamin A metabolites   cardiac function  

Academic Background Myocardial Infarction (MI) is one of the major global health concerns. Although myeloid cells in the bone marrow (BM) are crucial for tissue repair after MI, excessive myelopoiesis can exacerbate scarring and impair cardiac function. Hematopoietic stem cells (HSCs) in the bone marrow possess unique regenerative capabilities, ena...

Maternal Folic Acid Over-Supplementation Impairs Cardiac Function in Mice Offspring by Inhibiting SOD1 Expression

Medicine, Obstetrics and Gynecology, Cardiovascular System, Life Sciences,
folic acid   over-supplementation   cardiac function   superoxide dismutase 1   N-acetylcysteine  

Background Folic Acid (FA) supplementation during pregnancy is widely recommended to reduce the risk of fetal congenital defects, particularly in the prevention of neural tube defects and congenital heart disease. However, despite the significant benefits of FA supplementation in preventing certain diseases, whether excessive FA supplementation may...

Precision Imaging of Cardiac Function and Scar Size in Acute and Chronic Porcine Myocardial Infarction Using Ultral-high-field MRI

Precision Imaging of Cardiac Function and Scar Size in Acute and Chronic Porcine Myocardial Infarction Using Ultral-high-field MRI

Medicine, Medical Imaging, Cardiovascular System, Life Sciences, Biophysics,
ultrahigh field   myocardial infarction   cardiac function   porcine model   MRI   scar detection  

Precision Imaging of Cardiac Function and Infarct Scar Size: A Study with Ultrahigh-Field MRI in Acute and Chronic Porcine Models of Myocardial Infarction Research Background Cardiac magnetic resonance imaging (MRI) is an accurate and highly reproducible technique for assessing cardiac function and volume. In recent years, ultrahigh-field (UHF) MRI...