Brain Tumors Induce Widespread Disruption of Calvarial Bone and Alteration of Skull Marrow Immune Landscape

Medicine, Basic Medical Sciences, Neurology, Neurosurgery, Hematology, Medical Imaging, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
brain tumor   calvarial bone   skull marrow   immune microenvironment   single-cell RNA sequencing   osteoclast   immune cell alteration  

A New Role for Skull Marrow Immune Microenvironment in Brain Tumors: Interpretation Based on Multicenter Studies in Mice and Humans 1. Academic Background and Research Significance Brain tumors, especially glioblastoma (GBM), are among the most aggressive malignant tumors in the central nervous system. Traditionally, they were considered localized ...

Aberrant Engagement of P-selectin Drives Hematopoietic Stem Cell Aging in Mice

Medicine, Basic Medical Sciences, Geriatrics, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology,
P-selectin   hematopoietic stem cells   aging   gene expression   erythropoiesis   inflammation   stem cell regeneration  

1. Research Background and Scientific Problem The health of the hematopoietic system is crucial to the proper functioning of the body, with hematopoietic stem cells (HSCs) at its core in maintaining normal blood system operation. HSCs possess self-renewal and multipotent differentiation abilities, capable of generating all types of blood cells, inc...

Pace of Aging Analysis of Healthspan and Lifespan in Older Adults in the US and UK

Medicine, Respiratory System, Environmental and Public Health, Geriatrics, Neurology, Hematology, Life Sciences, Genetics,
pace of aging   healthspan   biomarkers   epidemiology   United States   United Kingdom   aging population  

— Longitudinal Population Analysis Based on the “Pace of Aging” Method 1. Research Background and Scientific Significance With the acceleration of global population aging, objectively measuring and improving the health status of the elderly has become an important issue in social policy and public health worldwide. Traditionally, measurements of po...

Mitochondria-Enriched Hematopoietic Stem Cells Exhibit Elevated Self-Renewal Capabilities Within the Context of Aged Bone Marrow

Medicine, Basic Medical Sciences, Geriatrics, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
hematopoietic stem cells   mitochondria   self-renewal   aging   bone marrow   single-cell analysis   cell differentiation  

Mitochondria-Enriched Hematopoietic Stem Cells Reveal Enhanced Self-Renewal Activity in Aged Bone Marrow: In-Depth Analysis of the Latest Study in Nature Aging I. Academic Background and Research Significance Hematopoietic stem cells (HSCs) are the essential foundation underlying life-long production of blood and immune cells. However, with aging, ...

Cellular Therapies for the Prevention and Treatment of Acute Graft-versus-Host Disease

Medicine, Rheumatology and Immunology, Hematology, Oncology, Life Sciences, Cell Biology, Immunology,
acute graft-versus-host disease   allogeneic hematopoietic cell transplantation   cellular therapy   T-cell depletion   mesenchymal stem cells   regulatory T cells   immunomodulation  

Advances in Cellular Therapies for the Prevention and Treatment of Acute Graft-versus-Host Disease (aGVHD) — An Authoritative Review on the Paper “Cellular therapies for the prevention and treatment of acute graft-versus-host disease” 1. Academic Background and Motivation Acute graft-versus-host disease (aGVHD) is one of the most severe complicatio...

Critical Role of the Potential O-Linked Glycosylation Sites of CXCR4 in Cell Migration and Bone Marrow Homing of Hematopoietic Stem Progenitor Cells

Medicine, Basic Medical Sciences, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology,
CXCR4   O-linked glycosylation   hematopoietic stem progenitor cells   cell migration   bone marrow homing   glycosylation   CXCL12  

1. Academic Background and Research Origin Hematopoietic stem/progenitor cells (HSPCs) are the foundation for maintaining the steady state of the adult blood system. Every day, the human body needs to generate billions of new blood cells—a process that relies on the capacity of HSPCs for self-renewal and directed differentiation within the bone mar...