Single-dose Psilocybin Rapidly and Sustainably Relieves Allodynia and Anxiodepressive-like Behaviors in Mouse Models of Chronic Pain

Medicine, Basic Medical Sciences, Psychiatry, Anesthesiology, Neurology, Clinical Psychology, Pharmacy,
chronic pain   psilocybin   allodynia   anxiodepression   5-HT receptors   prefrontal cortex   neural circuits  

Single-dose Psychedelic Rapidly and Sustainedly Relieves Chronic Pain and Emotional Disorders: Academic Report on New Original Research in Nature Neuroscience Background Chronic pain and emotional disorders (such as anxiety and depression) frequently co-occur in clinical settings, each exacerbating the other and affecting treatment outcomes. Clinic...

Nociceptor Spontaneous Activity is Responsible for Fragmenting Non-Rapid Eye Movement Sleep in Mouse Models of Neuropathic Pain

Medicine, Basic Medical Sciences, Anesthesiology, Neurology,
nociceptor   spontaneous activity   non-rapid eye movement sleep   mouse models   chronic pain  

Research Background and Motivation Neuropathic pain is a complex and common clinical issue, accompanied by persistent spontaneous pain. Patients often report symptoms such as spontaneous pain, electric shock sensations, and burning pain. The physiological mechanisms behind this type of pain are complex, and reliable research models or biomarkers ar...