Single-dose Psilocybin Rapidly and Sustainably Relieves Allodynia and Anxiodepressive-like Behaviors in Mouse Models of Chronic Pain

Medicine, Basic Medical Sciences, Psychiatry, Anesthesiology, Neurology, Clinical Psychology, Pharmacy,
chronic pain   psilocybin   allodynia   anxiodepression   5-HT receptors   prefrontal cortex   neural circuits  

Single-dose Psychedelic Rapidly and Sustainedly Relieves Chronic Pain and Emotional Disorders: Academic Report on New Original Research in Nature Neuroscience Background Chronic pain and emotional disorders (such as anxiety and depression) frequently co-occur in clinical settings, each exacerbating the other and affecting treatment outcomes. Clinic...

Spectinomycin-Loaded Antibacterial Polyvinyl Alcohol/Silver Oxide Nanobiocomposite Hydrogel: Synthesis, Characterization, Swelling, Cytotoxicity, and Controlled Drug Release Carrier

Chemistry, Polymer Chemistry, Materials Science, Medicine, Pharmacy, Life Sciences, Bioengineering,
Spectinomycin   Hydrogel   Polyvinyl Alcohol   Nanoparticles   Biosensor   Raman Spectroscopy  

Academic Background In the field of drug delivery, achieving long-term and controlled release of drugs is a significant research direction. Hydrogels, as materials with excellent biocompatibility and degradability, have been widely used in drug delivery, tissue engineering, and wound dressing. However, the low mechanical strength of traditional hyd...

Development and Characterization of Baricitinib Nanoemulgel with Antiarthritic Effect in Rats

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Rheumatology and Immunology, Pharmacy, Life Sciences, Bioengineering,
Baricitinib   Transdermal delivery   Nanoemulgel   Skin permeation   Antiarthritis activity  

Academic Background Rheumatoid Arthritis (RA) is a chronic autoimmune disease that primarily affects the synovial membrane of joints, leading to inflammation and erosive lesions. Approximately 0.5% to 1% of the global population is affected by this disease, particularly among the elderly, who often experience dysphagia, which limits the compliance ...

Sugarcane Wax-Based Solid Lipid Nanoparticles as an Atorvastatin Carrier: Characterization and In Vivo Evaluation of Antihyperlipidemic Activity in Rats

Chemistry, Medicinal Chemistry, Medicine, Pharmacy, Cardiovascular System,
Sugarcane wax   Solid lipid nanoparticles   Atorvastatin   In vivo studies   Antihyperlipidemic  

Academic Background Cardiovascular diseases, particularly atherosclerosis, are one of the leading causes of death globally. Elevated cholesterol levels are a major risk factor for atherosclerosis. Atorvastatin (ATV) is a widely used cholesterol-lowering drug, but its oral bioavailability is low, primarily due to first-pass metabolism. To improve th...

Targeting ADAR1 with a Small Molecule for the Treatment of Prostate Cancer

Chemistry, Medicinal Chemistry, Medicine, Urology, Pharmacy, Oncology,
prostate cancer   ADAR1   small molecule inhibitor   tumor immunity   RNA editing  

Academic Background Prostate cancer (PCA) is one of the most common malignancies in men, particularly in Western countries, where it is the second leading cause of cancer-related deaths among males. Although androgen signaling therapy is effective in the initial treatment of prostate cancer, most patients eventually relapse, and there is currently ...

Molecular Mechanism of the Arrestin-Biased Agonism of Neurotensin Receptor 1 by an Intracellular Allosteric Modulator

Chemistry, Medicinal Chemistry, Medicine, Basic Medical Sciences, Pharmacy, Life Sciences, Biochemistry,
G protein-coupled receptors   allosteric modulators   arrestin-biased agonism   neurotensin receptor 1   cryo-EM structures   signal transduction   drug discovery  

Academic Background G protein-coupled receptors (GPCRs) are the most abundant family of cell surface receptors in the human body and are also the most common targets of FDA-approved drugs. GPCRs play a crucial role in the treatment of various diseases, including pain, diabetes, cardiovascular diseases, and cancer. However, drug development targetin...