Single-dose Psilocybin Rapidly and Sustainably Relieves Allodynia and Anxiodepressive-like Behaviors in Mouse Models of Chronic Pain

Medicine, Basic Medical Sciences, Psychiatry, Anesthesiology, Neurology, Clinical Psychology, Pharmacy,
chronic pain   psilocybin   allodynia   anxiodepression   5-HT receptors   prefrontal cortex   neural circuits  

Single-dose Psychedelic Rapidly and Sustainedly Relieves Chronic Pain and Emotional Disorders: Academic Report on New Original Research in Nature Neuroscience Background Chronic pain and emotional disorders (such as anxiety and depression) frequently co-occur in clinical settings, each exacerbating the other and affecting treatment outcomes. Clinic...

The Role of Primary Motor Cortex in Chronic Pain Treatment

The Role of Primary Motor Cortex in Chronic Pain Treatment

Medicine, Anesthesiology, Neurology,
Primary Motor Cortex   Chronic Pain   Sensory-Motor Integration   Repetitive Transcranial Magnetic Stimulation   Descending Inhibitory System  

Chronic pain is a complex multidimensional experience involving sensory, emotional, and cognitive dimensions. Although traditional analgesic and antidepressant drugs are widely used, more than 50%-60% of chronic pain patients fail to benefit from them. Therefore, finding new treatment strategies has become an urgent need. In recent years, neuromodu...

Routine Anaesthesia Ward-Based Patient Visits in Surgery: 1-Year Outcomes of the TRACE Randomized Clinical Trial

Medicine, Anesthesiology,
anaesthesia ward visits   surgical outcomes   functional recovery   quality of life   randomized clinical trial  

In perioperative medicine, the long-term clinical and functional recovery of postoperative patients has always been a focus of research. Traditionally, postoperative complications, mortality, readmission rates, and reoperation rates have been the primary indicators for measuring surgical patient outcomes. However, as medical research deepens, an in...

Preoperative Stereotactic Radiotherapy to Prevent Pancreatic Fistula in High-Risk Patients Undergoing Pancreatoduodenectomy (FIBROPANC): Prospective Multicentre Phase II Single-Arm Trial

Medicine, Hepatobiliary System, Anesthesiology, Gastroenterology, Oncology,
pancreatic fistula   stereotactic radiotherapy   pancreatoduodenectomy   high-risk patients   fibrosis   safety   efficacy  

Pancreaticoduodenectomy is a common surgery for treating tumors of the pancreas and surrounding organs, but postoperative pancreatic fistula (POPF) is one of its major complications, especially in high-risk patients, where the incidence of POPF can be as high as 50%. POPF not only increases hospitalization time and medical costs but can also lead t...

WHO Disability Assessment Schedule 2.0: Responsiveness in Detecting Long-Term Functional Disability After Surgery

Medicine, Anesthesiology,
disability assessment   postoperative function   long-term responsiveness   WHO assessment   surgical recovery  

With advances in anesthesia, surgery, and intensive care management, the short-term perioperative outcomes of surgical patients have significantly improved. However, an increasing number of studies are focusing on long-term outcomes directly related to patient prognosis, such as functional recovery or functional disability. Functional disability is...

Multicentre Prospective Study on the Diagnostic and Prognostic Validity of Malnutrition Assessment Tools in Surgery

Medicine, Anesthesiology, Gastroenterology,
malnutrition   surgery   diagnostic tools   prognostic validity   multicentre study   nutritional assessment   postoperative complications  

Academic Background Malnutrition is a significant risk factor for postoperative complications, particularly in patients undergoing major abdominal surgery, where the incidence of malnutrition is high. However, there is currently no widely accepted tool for assessing malnutrition. Existing nutritional screening tools vary greatly in sensitivity and ...