Toxoplasma gondii Infection and Chronic IL-1 Elevation Drive Hippocampal DNA Double-Strand Break Signaling, Leading to Cognitive Deficits

Medicine, Infectious Diseases, Rheumatology and Immunology, Basic Medical Sciences, Psychiatry, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics, Microbiology,
Toxoplasma gondii infection   chronic inflammation   IL-1   hippocampus   DNA double-strand break   cognitive deficit   spatial memory  

Chronic Toxoplasma Infection and Elevated IL-1 Lead to Hippocampal Dysfunction via DNA Double-Strand Break Signaling: A Review of the Latest Nature Neuroscience 2025 Study Academic Background and Research Rationale In recent years, neuroinflammation has garnered increasing attention in the academic community due to its role in various brain disease...

A Pancreas–Hippocampus Feedback Mechanism Regulates Circadian Changes in Depression-Related Behaviors

Medicine, Psychiatry, Endocrinology, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
pancreas   hippocampus   circadian rhythm   depression   bipolar disorder   insulin secretion   behavioral changes  

Cutting Baseline Research Report in Nature Neuroscience: Pancreas–Hippocampus Feedback Mechanism Regulates Circadian Rhythm and Depression-Related Behaviors 1. Introduction and Academic Background In recent decades, the comorbidity of neuropsychiatric disorders and metabolic dysregulation has become a research hotspot in neuroscience and psychiatri...

Psychedelic 5-HT2A Receptor Agonism Alters Neurovascular Coupling and Differentially Affects Neuronal and Hemodynamic Measures of Brain Function

Medicine, Basic Medical Sciences, Psychiatry, Neurology, Medical Imaging, Life Sciences, Biochemistry, Biophysics,
psychedelics   5-HT2A receptor   neurovascular coupling   brain function   hemodynamics   optical imaging   functional connectivity  

Mechanisms of Psychedelics in Neurovascular Coupling: A Latest Research Interpretation 1. Academic Background and Research Motivation In the past decade, psychedelics such as psilocybin and lysergic acid diethylamide (LSD) have regained high attention in the scientific community due to their rapid and significant efficacy in clinical fields such as...

A lateral hypothalamic neuronal population expressing leptin receptors counteracts anxiety to enable adaptive behavioral responses

Medicine, Psychiatry, Endocrinology, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
lateral hypothalamus   leptin receptors   anxiety   adaptive behavior   neurons   exploration   eating disorders  

Nature Neuroscience Major Publication – How Leptin Receptor Neurons in the Hypothalamus Counteract Anxiety and Regulate Adaptive Behavior 1. Academic Background: The Dynamic Balance Between Anxiety and Survival Behaviors Anxiety is a protective emotional state that prevents individuals from exposure to potential danger and maintains safety. However...

Single-dose Psilocybin Rapidly and Sustainably Relieves Allodynia and Anxiodepressive-like Behaviors in Mouse Models of Chronic Pain

Medicine, Basic Medical Sciences, Psychiatry, Anesthesiology, Neurology, Clinical Psychology, Pharmacy,
chronic pain   psilocybin   allodynia   anxiodepression   5-HT receptors   prefrontal cortex   neural circuits  

Single-dose Psychedelic Rapidly and Sustainedly Relieves Chronic Pain and Emotional Disorders: Academic Report on New Original Research in Nature Neuroscience Background Chronic pain and emotional disorders (such as anxiety and depression) frequently co-occur in clinical settings, each exacerbating the other and affecting treatment outcomes. Clinic...

Oxytocin Modulates Respiratory Heart Rate Variability Through a Hypothalamus–Brainstem–Heart Neuronal Pathway

Medicine, Respiratory System, Basic Medical Sciences, Psychiatry, Endocrinology, Neurology, Cardiovascular System, Life Sciences, Biochemistry,
oxytocin   respiratory heart rate variability   hypothalamus-brainstem pathway   cardiac regulation   vagus nerve   stress recovery   neural modulation  

Latest Nature Neuroscience Research Report: A Novel Central Mechanism of Oxytocin in Regulating Respiratory Heart Rate Variability 1. Research Background and Disciplinary Foundation Heart rate variation is an important indicator reflecting both physiological and psychological states in humans, finely regulated by the autonomic nervous system to mai...

MASA-TCN: Multi-Anchor Space-Aware Temporal Convolutional Neural Networks for Continuous and Discrete EEG Emotion Recognition

Information Science, Computer Science, Artificial Intelligence, Medicine, Psychiatry, Neurology, Clinical Psychology, Medical Imaging,
EEG signals   emotion recognition   temporal convolutional neural network   space-aware   continuous regression   discrete classification   multi-anchor fusion  

A Breakthrough in EEG Emotion Recognition: The Proposal and Experimental Analysis of the MASA-TCN Unified Model Academic Background and Research Motivation Human emotion recognition has long been a popular research direction in neuroscience, artificial intelligence, and human-computer interaction. Automatic identification of individual emotional st...

AV-FOS: Transformer-Based Audio-Visual Multimodal Interaction Style Recognition for Children with Autism Using the Revised Family Observation Schedule 3rd Edition (FOS-R-III)

Information Science, Computer Science, Artificial Intelligence, Medicine, Pediatrics, Psychiatry, Clinical Psychology, Medical Imaging,
autism spectrum disorder   challenging behaviors   multimodal learning   self-supervised learning   video understanding   interaction style recognition   clinical observation  

1. Background: Clinical Challenges and Technological Prospects in Behavior Monitoring of Children with Autism Autism Spectrum Disorder (ASD, autism) is a lifelong neurodevelopmental disorder. In recent years, the prevalence of autism in the United States has risen rapidly, with current epidemiological data indicating that one in every 36 children i...