Phosphoantigen-Induced Inside-Out Stabilization of Butyrophilin Receptor Complexes Drives Dimerization-Dependent γδ TCR Activation

Medicine, Rheumatology and Immunology, Life Sciences, Cell Biology, Biochemistry, Immunology, Biophysics,
phosphoantigens   Butyrophilin receptor complexes   γδ TCR   dimerization   cell activation  

Academic Background γδ T cells are a unique subset of the immune system, characterized by T cell receptors (TCRs) composed of γ and δ chains that recognize non-peptide antigens, such as phosphoantigens (PAgs) produced by microbial or tumor cells. Among them, Vγ9Vδ2 T cells are the most abundant γδ T cell subset in human circulation and play a criti...