Local and Distal Dynamic Changes Caused by the L205R Cushing’s Syndrome Mutant in PRKACA

New Insights into the Molecular Dynamics and Allosteric Network Regulation Mechanisms of the Common Cushing’s Syndrome Mutation L205R in Protein Kinase A: Interpreting the Latest Original Research from PNAS I. Research Background and Scientific Questions Protein kinase A (PKA) is a key intracellular signal transduction molecule that regulates a var...

Acetylation of c-Myc at Lysine 148 Protects Neurons After Ischemia

Research Background This study explores the role of the cancer-related transcription factor c-myc in penumbra neurons following ischemic stroke. Although the role of c-myc in cell death and survival has been recognized, research on its post-translational modifications, especially acetylation, in ischemic models remains insufficient. Investigating t...