Cutting Baseline Research Report in Nature Neuroscience: Pancreas–Hippocampus Feedback Mechanism Regulates Circadian Rhythm and Depression-Related Behaviors 1. Introduction and Academic Background In recent decades, the comorbidity of neuropsychiatric disorders and metabolic dysregulation has become a research hotspot in neuroscience and psychiatri...
Nature Neuroscience Major Publication – How Leptin Receptor Neurons in the Hypothalamus Counteract Anxiety and Regulate Adaptive Behavior 1. Academic Background: The Dynamic Balance Between Anxiety and Survival Behaviors Anxiety is a protective emotional state that prevents individuals from exposure to potential danger and maintains safety. However...
Latest Nature Neuroscience Research Report: A Novel Central Mechanism of Oxytocin in Regulating Respiratory Heart Rate Variability 1. Research Background and Disciplinary Foundation Heart rate variation is an important indicator reflecting both physiological and psychological states in humans, finely regulated by the autonomic nervous system to mai...
Mechanistic Study on How Retrotransposon-derived Capsid Genes PNMA1 and PNMA4 Maintain Reproductive Capacity — A New Research Review from Nature Aging I. Research Background and Scientific Significance Nearly half of the DNA in the human and mammalian genome is made up of retrotransposons, sequences that originally existed as “parasitic molecules” ...
I. Research Background and Scientific Question Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide, with pathological features mainly including neuronal loss, neurofibrillary tangles, and senile plaques (mainly formed by amyloid-β [Aβ] deposition). According to statistics, the number of AD patients continues to rise each...
Background Introduction Diabetes, especially type 1 diabetes (T1D), is a chronic autoimmune disease characterized by the persistent destruction of pancreatic β cells by the immune system, resulting in the loss of the ability to regulate blood glucose. Patients with type 1 diabetes typically require lifelong insulin injections; however, long-term in...
Academic Research Background With the global population aging rapidly, osteoporosis has gradually become a major disease threatening public health. Characterized by reduced bone mass and deterioration of bone microarchitecture, osteoporosis significantly increases the risk of fractures, severely impacts the quality of life of the elderly, and bring...