Clinical Significance of Stratifying Prostate Cancer Patients Through Specific Circulating Genes

Medicine, Urology, Oncology,
prostate cancer   circulating genes   liquid biopsy   biomarker   drug target   neuroendocrine   stem cell  

Clinical Significance of Stratifying Prostate Cancer Patients Through Specific Circulating Genes Academic Background Prostate Cancer (PCA) is the most common cancer among men in North America and a leading cause of cancer-related mortality. Although many patients are diagnosed with organ-confined disease, 25-35% experience recurrence after curative...

Assessments of Prostate Cancer Cell Functions Highlight Differences Between a Pan-PI3K/mTOR Inhibitor, Gedatolisib, and Single-Node Inhibitors of the PI3K/AKT/mTOR Pathway

Medicine, Urology, Oncology,
prostate cancer   PI3K/AKT/mTOR pathway   Gedatolisib   single-node inhibitors   cell functions  

Prostate Cancer Cell Function Assessments Reveal Differences Between Gedatolisib and Single-Node PI3K/AKT/mTOR Inhibitors Academic Background Prostate cancer (PC) is one of the most common cancers among men worldwide, particularly in advanced stages where patients often develop resistance to androgen deprivation therapy (ADT), progressing to castra...

A TBX2-Driven Signaling Switch from Androgen Receptor to Glucocorticoid Receptor Confers Therapeutic Resistance in Prostate Cancer

Medicine, Urology, Endocrinology, Oncology,
prostate cancer   therapeutic resistance   TBX2   androgen receptor   glucocorticoid receptor   signaling switch   SP2509  

Academic Background and Problem Statement Prostate Cancer (PCA) is one of the most common malignancies in men, particularly in advanced stages, where patients typically receive Androgen Deprivation Therapy (ADT) as the standard treatment. However, despite initial treatment efficacy, patients eventually develop Castration-Resistant Prostate Cancer (...

PSMA-PET/CT Findings in Patients with High-Risk Biochemically Recurrent Prostate Cancer with No Metastatic Disease by Conventional Imaging

Medicine, Urology, Medical Imaging, Oncology,
prostate cancer   PSMA-PET/CT   biochemical recurrence   high-risk   imaging   metastasis   treatment guidance  

Academic Background Prostate cancer is one of the most common cancers in men worldwide, particularly in Western countries. Despite advances in early diagnosis and treatment significantly improving survival rates, cancer recurrence remains a major clinical challenge. This is particularly true for patients with high-risk nonmetastatic hormone-sensiti...

Exosomal PSM-E Inhibits Macrophage M2 Polarization to Suppress Prostate Cancer Metastasis Through the RACK1 Signaling Axis

Medicine, Urology, Oncology,
prostate cancer   exosomes   macrophage polarization   RACK1 signaling pathway   tumor microenvironment  

Exosomal PSM-E Inhibits Macrophage M2 Polarization to Suppress Prostate Cancer Metastasis via the RACK1 Signaling Axis Academic Background Prostate cancer (PCA) is a prevalent cancer among men and the second leading cause of cancer-related deaths. While early-stage prostate cancer can be treated with surgery or radiotherapy, approximately one-third...