TDP-43 Nuclear Loss in FTD/ALS Causes Widespread Alternative Polyadenylation Changes

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
TDP-43   frontotemporal dementia   amyotrophic lateral sclerosis   RNA processing   alternative polyadenylation   neurodegeneration   biomarker  

Introduction and Academic Background Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are two severe neurodegenerative diseases whose pathogenic mechanisms remain incompletely understood. In recent years, the RNA-binding protein TDP-43 (TAR DNA-binding protein 43) has been recognized as playing a central pathological role in bo...

TP53-Specific Mutations Serve as a Potential Biomarker for Homologous Recombination Deficiency in Breast Cancer: A Clinical Next-Generation Sequencing Study

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
next-generation sequencing   homologous recombination deficiency   TP53   breast cancer   biomarker  

Breast cancer is one of the most common malignant tumors among women worldwide, with a complex pathogenesis involving multiple gene mutations and signaling pathway abnormalities. Homologous Recombination Deficiency (HRD) is a significant molecular characteristic in breast cancer, closely related to patients’ sensitivity to PARP inhibitor (PARPi) th...

Hydrogen Gas and the Gut Microbiota as Potential Biomarkers for the Development of Experimental Colitis in Mice

Medicine, Gastroenterology, Life Sciences, Immunology, Microbiology,
gut microbiota   hydrogen gas   experimental colitis   inflammatory bowel disease   biomarker  

Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition that primarily includes Ulcerative Colitis (UC) and Crohn’s Disease (CD). The incidence of IBD has been increasing globally, imposing significant health and economic burdens on patients and society. Currently, the diagnosis of IBD relies mainly on endoscopy, but this method is exp...

Anxiety Disorder Identification with Biomarker Detection through Subspace-Enhanced Hypergraph Neural Network

Anxiety Disorder Identification with Biomarker Detection through Subspace-Enhanced Hypergraph Neural Network

Information Science, Artificial Intelligence, Medicine, Psychiatry, Medical Imaging, Life Sciences, Bioengineering,
anxiety disorder   hypergraph neural network   multimodal data   subspace enhancement   biomarker  

Anxiety Disorder Identification and Biomarker Detection Based on Subspace-Enhanced Hypergraph Neural Network Academic Background Anxiety Disorders (ADs) are prevalent mental health issues globally, affecting approximately 7.3% of the population. Patients with anxiety disorders typically exhibit excessive fear, worry, and related behavioral abnormal...

Biomarkers Associated with Progression of Infantile Hemangioma: Exploratory Study

Medicine, Pediatrics, Medical Laboratory Science, Oncology, Life Sciences, Immunology,
infantile hemangioma   biomarker   GDF1   IL-7Rα   proliferation   treatment   plasma cytokines  

Biomarkers Associated with the Progression of Infantile Hemangioma: An Exploratory Study Academic Background Infantile Hemangioma (IH) is one of the most common benign tumors in infancy. Although most IH is not apparent at birth, it gradually manifests within the first month of life and undergoes a proliferative phase over approximately one year, f...

Clinical Significance of Stratifying Prostate Cancer Patients Through Specific Circulating Genes

Medicine, Urology, Oncology,
prostate cancer   circulating genes   liquid biopsy   biomarker   drug target   neuroendocrine   stem cell  

Clinical Significance of Stratifying Prostate Cancer Patients Through Specific Circulating Genes Academic Background Prostate Cancer (PCA) is the most common cancer among men in North America and a leading cause of cancer-related mortality. Although many patients are diagnosed with organ-confined disease, 25-35% experience recurrence after curative...