Overexpression of ZIC1 Transcription Factor in Segmental Bone Defects Promotes Brown Adipogenic and Osteogenic Differentiation

1. Academic Background and Research Significance Human bone tissue possesses a certain degree of self-healing capability. However, after suffering from severe trauma, tumor resection, infection, or congenital deformity, leading to large-volume bone defects, this regenerative ability becomes limited. The so-called “critical size bone defect” refers ...