A Novel Formulation of Docetaxel-Containing Micelle Surface Modified with Metronidazole to Target Tumor Hypoxia

Chemistry, Medicinal Chemistry, Medicine, Oncology, Life Sciences, Bioengineering,
tumor hypoxia   metronidazole   active targeting   micelle   docetaxel  

Background Introduction Cancer is one of the leading causes of death globally, and despite significant progress in treatment, the complexity of tumors, particularly tumor hypoxia, remains a major obstacle to successful therapy. Hypoxic regions are prevalent in solid tumors, where oxygen concentrations are significantly lower than in normal tissues ...

Light/pH Dual Controlled Drug Release 'Nanocontainer' Alleviates Tumor Hypoxia for Synergistic Enhanced Chemotherapy, Photodynamic Therapy, and Chemodynamic Therapy

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Oncology, Life Sciences, Bioengineering,
nanocontainer   tumor hypoxia   photodynamic therapy   chemodynamic therapy   Fenton effect   multimodal therapy   targeted therapy  

Light/pH Dual-Controlled Drug Release “Nanocontainer” Alleviates Tumor Hypoxia for Synergistic Enhanced Chemotherapy, Photodynamic Therapy, and Chemodynamic Therapy Academic Background In clinical cancer treatment, chemotherapy and radiotherapy have several limitations, such as drug resistance, incomplete treatment, and periodic recurrence. To over...