Academic Background DNA damage repair (DDR) is a core mechanism for maintaining genome stability, and its dysfunction is closely associated with cancer development. Valosin-containing protein (VCP/p97), a member of the AAA+ ATPase family, plays a critical role in DDR by recognizing ubiquitinated proteins and recruiting repair factors (e.g., 53BP1, ...
Academic Background Proton transfer plays a central role in biological energy conversion (e.g., ATP synthesis) and signal transduction. Traditional theory posits that protons move via a “hopping mechanism” through water chains or amino acid side chains, while the recently proposed “proton-coupled electron transfer” (PCET) hypothesis suggests that e...
Academic Background RNA, as a carrier of genetic information and functional molecule, has long been considered an “undruggable” target. In recent years, with advances in RNA structural biology, scientists have begun exploring the development of small-molecule drugs targeting RNA. However, this field faces three core challenges: (1) lack of systemat...
Academic Background G protein-coupled receptors (GPCRs) are the largest family of membrane proteins in the human body, transmitting extracellular signals through heterotrimeric G proteins (composed of Gα and Gβγ subunits). G proteins function as molecular switches, with their activity states regulated by the GTP/GDP cycle: - Inactive state: Gα bind...
Academic Background Microbiomes are among the most diverse ecosystems on Earth, consisting of hundreds of functionally distinct microbial populations interacting through complex resource exchange networks. However, a long-standing unresolved question is: How is this extraordinary diversity maintained through metabolic interactions among populations...
Academic Background and Research Motivation With the growing demand for the analysis of complex samples, chromatographic technologies—especially comprehensive two-dimensional gas chromatography coupled with mass spectrometry (GC×GC–MS)—have emerged as a powerhouse for untargeted metabolomics and related fields, demonstrating exceptional resolving p...
Academic Background and Research Motivation In recent years, protein–ligand docking has rapidly developed as a core technology for virtual drug screening and structure-based drug discovery. Despite improvements in drug discovery efficiency through large-scale high-throughput screening technologies, new drug development still faces high costs, long ...
Academic Background Organic light-emitting diode (OLED) technology has made remarkable progress in recent years, especially in the field of thermally activated delayed fluorescence (TADF) materials. TADF materials achieve high-efficiency emission by converting triplet excitons into singlet excitons through the reverse intersystem crossing (RISC) pr...
Academic Background Photosynthetic microorganisms can directly convert carbon dioxide (CO₂) into high value-added long-chain chemicals by converting solar energy into chemical energy, providing a promising route for CO₂ sequestration and sustainable development. However, the key reducing power generated in photosynthetic reactions—nicotinamide aden...
Academic Background Direct Borohydride Fuel Cells (DBFCs), as a potential carbon-neutral energy source, have attracted considerable attention due to their use of sodium borohydride (NaBH4) as the anode fuel. NaBH4 possesses advantages such as portability, non-toxicity, water solubility, and environmental stability, allowing DBFCs in theory to deliv...