VCP's Nuclear Journey: Initiated by Interacting with KPNB1 to Repair DNA Damage

Chemistry, Medicinal Chemistry, Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
DNA damage repair   VCP   KPNB1   nuclear translocation   Withaferin A  

Academic Background DNA damage repair (DDR) is a core mechanism for maintaining genome stability, and its dysfunction is closely associated with cancer development. Valosin-containing protein (VCP/p97), a member of the AAA+ ATPase family, plays a critical role in DDR by recognizing ubiquitinated proteins and recruiting repair factors (e.g., 53BP1, ...

RFC4 Confers Radioresistance of Esophagus Squamous Cell Carcinoma through Regulating DNA Damage Response

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
RFC4   esophageal squamous cell carcinoma   radioresistance   DNA damage repair   p53 signaling pathway  

New Discovery in the Mechanism of Radioresistance in Esophageal Squamous Cell Carcinoma: The Role of the RFC4 Gene Academic Background Esophageal squamous cell carcinoma (ESCC) is one of the most common gastrointestinal malignancies in China, and radiotherapy is a crucial treatment modality. However, radioresistance in tumor cells is a major cause ...