1. Research Background The Parkinson’s disease-associated protein PARK7/DJ-1 (hereafter referred to as PARK7) is a multifunctional protein that plays critical roles in various pathological conditions including neurodegenerative diseases, cancer, and inflammation. Despite lacking a conventional N-terminal signal peptide sequence, PARK7 can be secret...

Syntaxin 4-Enhanced Plasma Membrane Repair is Independent of Dysferlin in Skeletal Muscle Background Introduction Plasma membrane repair (PMR) is a crucial process for cells to maintain membrane integrity, preventing cell death, especially in vital organs such as skeletal muscle. Dysferlin, a sarcolemmal calcium-binding protein, has been shown to p...