Gut Microbiota-Dependent Increase in Phenylacetic Acid Induces Endothelial Cell Senescence During Aging

Medicine, Geriatrics, Gastroenterology, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Microbiology,
gut microbiota   phenylacetic acid   endothelial cell senescence   aging mechanisms   cardiovascular disease   oxidative stress  

Molecular Mechanisms of Gut Microbiota and Its Metabolites Mediating Endothelial Cell Senescence During Aging – Interpretation of Latest Results from Nature Aging I. Research Background and Significance Against the backdrop of a deeply aging human society, cardiovascular disease (CVD) has become one of the greatest health threats to the global elde...

Unconventional Secretion of Park7 Requires Lysosomal Delivery via Chaperone-Mediated Autophagy and Specialized SNARE Complex

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology, Biophysics,
unconventional secretion   Park7/DJ-1   autophagy   SNARE complex   oxidative stress  

1. Research Background The Parkinson’s disease-associated protein PARK7/DJ-1 (hereafter referred to as PARK7) is a multifunctional protein that plays critical roles in various pathological conditions including neurodegenerative diseases, cancer, and inflammation. Despite lacking a conventional N-terminal signal peptide sequence, PARK7 can be secret...

Effectiveness of Chitosan Nanoparticles as a Radioprotective Agent Against Gamma-Induced Changes in the Histology and Biochemistry of Parotid Glands

Chemistry, Nanoscience, Medicine, Oncology, Life Sciences, Biochemistry, Bioengineering,
chitosan nanoparticles   radioprotection   parotid glands   oxidative stress   survival rate  

Cancer is one of the leading causes of death worldwide. Radiotherapy, as a crucial method for cancer treatment, effectively kills cancer cells but also damages normal tissues, especially sensitive tissues such as salivary glands. The oxidative stress and inflammatory reactions induced by radiotherapy are the primary causes of salivary gland dysfunc...

Novel Endocytosis Inhibitors Block Entry of HIV-1 Tat into Neural Cells

Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases, Neurology, Life Sciences, Biochemistry, Immunology,
HIV-1 Tat   endocytosis inhibitors   oxidative stress   DNA damage   neural cells  

Novel Endocytosis Inhibitors Block HIV-1 Tat Protein Entry into Neural Cells Academic Background HIV-1 (human immunodeficiency virus type 1) infection not only leads to immune system exhaustion but is also closely associated with HIV-associated neurocognitive disorders (HAND). Although combined antiretroviral therapy (cART) has significantly improv...

Macrophage Membrane-Camouflaged Nanozymes for Combating Oxidative Stress-Microvascular Perfusion Negative Feedback in Ischemia-Reperfusion Induced Acute Kidney Injury

Chemistry, Nanoscience, Medicine, Nephrology, Life Sciences, Biochemistry, Bioengineering, Immunology,
acute kidney injury   macrophage membrane   nanozymes   oxidative stress   microvascular perfusion   renal ischemia-reperfusion   anti-inflammatory therapy  

Innovative Research Report on Intravenous Macrophage Membrane-Camouflaged Nanozymes for Acute Kidney Injury Targeted Therapy Background Introduction Acute kidney injury (AKI) is a severe clinical syndrome characterized by a rapid decline in renal function and is closely associated with high morbidity and mortality. Statistics show that the incidenc...