Academic Background and Problem Introduction Chronic Myeloid Leukemia (CML) is a hematologic malignancy driven by the BCR-ABL1 fusion gene. Although Tyrosine Kinase Inhibitors (TKIs) have significantly improved the survival rate of CML patients, TKI resistance and disease progression to the blast crisis (BC) phase remain major challenges in clinica...

ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer Academic Background and Research Motivation Existing research evidence suggests that cancer cell lineage plasticity and epigenetic reprogramming enable them to evade lineage-dependent targeted therapy by adopting lineage plasticity. Howev...