Epigenetic Editing at Individual Age-Associated CpGs Affects the Genome-wide Epigenetic Aging Landscape

Medicine, Basic Medical Sciences, Geriatrics, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
epigenetic editing   DNA methylation   CpG sites   aging biomarkers   genome-wide   CRISPR   bystander effects  

Unveiling the Mystery of the Epigenetic Aging Clock: A Review of Research on the Impact of Epigenetic Editing at Single Age-Associated CpG Sites on the Genome-wide Epigenetic Aging Landscape I. Research Background and Scientific Questions Epigenetics, especially DNA methylation, has become a cutting-edge frontier in aging mechanism research in rece...

Development and Validation of a Proteomic Signature of Healthspan

Medicine, Environmental and Public Health, Medical Laboratory Science, Geriatrics, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology, Genetics,
healthspan   proteomics   biological aging biomarkers   aging biomarkers   UK Biobank   healthy aging  

1. Academic Background: From Lifespan Extension to the Enhancement of Healthspan With the improvement of global medical and socioeconomic standards since the 20th century, overall human lifespan has significantly increased, especially in developing countries. However, healthspan—the number of years an individual lives in a state of complete health,...

Recommendations for Implementing the HEvolution Alliance for Aging Biomarkers Initiative

Medicine, Geriatrics, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology, Genetics,
aging biomarkers   health expectancy   geroscience   biological age   longitudinal studies  

Promoting Healthy Longevity: Implementation Recommendations for the Hevolution Alliance for Aging Biomarkers Initiative Academic Background and Research Motivation With the intensification of global population aging, human life expectancy has significantly increased, but the growth in healthy life expectancy (i.e., years lived in good health) has b...