METTL3 Mediates Atheroprone Flow–Induced Glycolysis in Endothelial Cells

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Biochemistry, Immunology,
glycolysis   endothelial cells   atherosclerosis   METTL3   flow   RNA modification   metabolic reprogramming  

1. Research Background Atherosclerosis is the primary pathological basis of cardiovascular diseases, closely associated with endothelial cell (EC) dysfunction. Hemodynamic factors play a critical role in the regional selectivity of atherosclerosis: oscillatory shear stress (OS) (e.g., at vascular bifurcations) promotes plaque formation, while pulsa...

Insulin Receptors in Vascular Smooth Muscle Cells Regulate Plaque Stability of Atherosclerosis

Medicine, Endocrinology, Cardiovascular System,
insulin receptor   smooth muscle cells   atherosclerosis   thrombospondin 1   inflammation   apoptosis   extracellular matrix  

Research Background Cardiovascular diseases (CVD) are one of the leading causes of death worldwide, particularly among patients with diabetes and insulin resistance, where the risk of CVD is significantly elevated. Although the prognosis for diabetic patients has improved in recent years, their CVD-related mortality rate remains 2 to 7 times higher...

Surgical Outcomes of Low-Flow Bypass Surgery in Intracranial Atherosclerotic Steno-Occlusive Diseases

Medicine, Neurosurgery,
atherosclerosis   stenosis   occlusion   bypass surgery   stroke  

This is a report on a scholarly article regarding the treatment results of low-bypass surgery for 215 patients with intracranial atherosclerotic stenosis or occlusion at Seoul National University Hospital. Background Introduction: Intracranial atherosclerotic disease (ICAD) causing stenosis or occlusion is one of the major causes leading to ischemi...