Augmenting AMPA Receptor Signaling After Spinal Cord Injury Increases Ependymal-Derived Neural Stem/Progenitor Cell Migration and Promotes Functional Recovery

Medicine, Basic Medical Sciences, Neurology, Neurosurgery, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
spinal cord injury   ependymal cells   neural stem cells   AMPA receptors   cell migration   functional recovery  

Enhancement of AMPA Receptor Signaling After Spinal Cord Injury Promotes Ependymal-Derived Neural Stem/Progenitor Cell Migration and Functional Recovery —— Synopsis of the Latest Research in Nature Neuroscience 1. Academic Background: Challenges in Spinal Cord Injury Repair, Potential of Ependymal Cells, and Exploration of AMPA Receptor Mechanisms ...

Brain Tumors Induce Widespread Disruption of Calvarial Bone and Alteration of Skull Marrow Immune Landscape

Medicine, Basic Medical Sciences, Neurology, Neurosurgery, Hematology, Medical Imaging, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
brain tumor   calvarial bone   skull marrow   immune microenvironment   single-cell RNA sequencing   osteoclast   immune cell alteration  

A New Role for Skull Marrow Immune Microenvironment in Brain Tumors: Interpretation Based on Multicenter Studies in Mice and Humans 1. Academic Background and Research Significance Brain tumors, especially glioblastoma (GBM), are among the most aggressive malignant tumors in the central nervous system. Traditionally, they were considered localized ...

Flash Radiation Reprograms Lipid Metabolism and Macrophage Immunity and Sensitizes Medulloblastoma to CAR-T Cell Therapy

Medicine, Pediatrics, Neurology, Neurosurgery, Oncology, Life Sciences, Immunology,
Flash radiation   Lipid metabolism   Macrophage   Medulloblastoma   CAR-T cell therapy   Immunosuppression   Tumor microenvironment  

Background Brain tumors, particularly medulloblastoma (MB) in children, are one of the leading causes of cancer-related deaths in pediatric populations. Despite advancements in treatments such as surgical resection, radiotherapy, and chemotherapy, the prognosis for high-risk MB remains poor. In recent years, immunotherapy, especially CAR-T cell the...

TRIM21-Mediated Ubiquitination and Phosphorylation of ERK1/2 Promotes Cell Proliferation and Drug Resistance in Pituitary Adenomas

Medicine, Endocrinology, Neurology, Neurosurgery, Oncology,
TRIM21   ERK1/2   pituitary adenomas   cell proliferation   drug resistance   ubiquitination   phosphorylation  

Academic Background Pituitary adenomas (PAs) are common intracranial tumors with complex pathogenesis, often accompanied by abnormal hormone secretion. Although various treatments, such as dopamine agonists (DAs), are currently available, some patients exhibit drug resistance, leading to suboptimal therapeutic outcomes. Therefore, identifying new t...

Phase II Trial of Pathology-Based Tripartite Treatment Stratification for Patients with CNS Germ Cell Tumors: A Long-Term Follow-Up Study

Medicine, Neurology, Neurosurgery, Oncology,
CNS germ cell tumors   long-term follow-up   tripartite treatment   pathology   survival rates   relapse   complications  

Long-Term Follow-Up Study of Central Nervous System Germ Cell Tumors: Pathology-Based Tripartite Treatment Stratification Academic Background Central nervous system germ cell tumors (CNS GCTs) are rare tumors primarily occurring in adolescents, especially males aged 12 to 16. These tumors are believed to originate from primordial germ cells (PGCs),...

Prospective Longitudinal Analysis of Physiologic MRI-Based Tumor Habitat Predicts Short-Term Patient Outcomes in IDH-Wildtype Glioblastoma

Medicine, Neurology, Neurosurgery, Medical Imaging, Oncology,
glioblastoma   tumor habitat   physiologic MRI   prognosis prediction   IDH-wildtype  

Prospective Longitudinal Analysis of Physiologic MRI-Based Tumor Habitat Predicts Short-Term Patient Outcomes in IDH-Wildtype Glioblastoma Academic Background Glioblastoma (GBM) is a highly malignant brain tumor characterized by significant intratumoral heterogeneity, which is evident not only in gene expression and histopathology but also in macro...