C9orf72 Hexanucleotide Repeat Expansions Impair Microglial Response in ALS

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
C9orf72   hexanucleotide repeat expansion   microglia   amyotrophic lateral sclerosis   single-nuclei transcriptome   endolysosomal pathway   genetic mechanism  

C9orf72 Hexanucleotide Repeat Expansions Impair Microglial Response in ALS Patients — In-depth Report on the November 2025 Issue of Nature Neuroscience 1. Academic Background and Research Motivation Amyotrophic lateral sclerosis (ALS) is a disabling neurodegenerative disease characterized by progressive loss of motor neurons, with most patients dyi...