Academic Background Microglia are the only resident macrophages in the central nervous system (CNS) and play critical roles in development, homeostasis, and disease. Traditionally, microglia were viewed as homogeneous “resting” or “activated” states, but the advent of single-cell sequencing technologies has revealed their remarkable transcriptional...
Academic Background Krabbe disease (also known as globoid cell leukodystrophy, GLD) is a fatal pediatric neurodegenerative disorder caused by mutations in the galactosylceramidase (GALC) gene. A hallmark pathological feature of this disease is the presence of lipid-laden globoid cells (GCs) in the central nervous system (CNS). Currently, hematopoie...
Academic Background The homeostasis of the central nervous system (CNS) relies on two key types of macrophages: microglia and border-associated macrophages (BAMs). Traditionally, microglia are believed to originate from the embryonic yolk sac and possess lifelong self-renewal capabilities, while bone marrow (BM)-derived monocytes in adults cannot r...
Study on the Propagation of Neuronal Micronuclei Regulating Microglial Characteristics Academic Background Microglia, the resident immune cells in the central nervous system (CNS), play a crucial role in maintaining brain homeostasis, regulating neuronal development, synaptic pruning, and responding to pathological states. However, despite extensiv...
Microglia and Macrophages in Glioblastoma Academic Background Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system, characterized by high invasiveness and lethality. Despite standard treatments such as surgery, chemotherapy, and radiotherapy, the survival rate of patients remains extremely limited, with a medi...
Background Introduction Sepsis is a life-threatening multiple organ dysfunction syndrome caused by uncontrolled infection in the host, and is one of the leading causes of death in intensive care units. It is reported that there are approximately 189 adult sepsis hospitalization cases per 100,000 person-years, with a mortality rate of 26.7%. Sepsis-...
TREM2 Expression on Mouse Astrocytes Prevents Sevoflurane-Induced Developmental Neurotoxicity Through Microglial Pruning of Dendritic Spines in Hippocampal CA1 Region Research Background and Significance Sevoflurane is one of the most widely used anesthetics in pediatric anesthesia. Early multiple exposures to sevoflurane can lead to developmental ...
Research on the Effects of Amorfrutin B on Human Microglia under Hypoxia/Ischemia Conditions: Anti-inflammatory Action, Proliferation Potential, and Mitochondrial State Based on the PPARγ Pathway Research Background Hypoxia/ischemia is a major cause of brain injury in both neonatal and adult populations. Perinatal asphyxia and ischemic stroke are l...
Repeated Low-Dose Lipopolysaccharide Pretreatment Improves Behavioral Abnormalities and Aberrant Immune Responses Induced by Repeated Social Defeat Stress Background Stress significantly impacts human health, with chronic stress particularly inducing various physiological and psychological disorders. The hypothalamic-pituitary-adrenal (HPA) axis is...
The Sirtuin 5 Inhibitor MC3482 Ameliorates Microglia-Induced Neuroinflammation following Ischaemic Stroke by Upregulating the Succinylation Level of Annexin-A1 Background Ischaemic stroke is the most common type of stroke and a leading cause of death and disability worldwide. Its pathogenesis is complex, involving processes such as oxidative stress...