Consistent Self-Organized Emergence of Hyaline Cartilage in hiPSC-Derived Multi-Tissue Organoids

Medicine, Orthopedics, Basic Medical Sciences, Life Sciences, Cell Biology, Bioengineering,
hyaline cartilage   multi-tissue organoids   human induced pluripotent stem cells   xeno-free culture   cartilage regeneration   gene regulatory networks  

Breakthrough Study on Consistent Self-Organized Formation of Hyaline Cartilage in hiPSC-Derived Multi-Tissue Organoids I. Academic Background 1.1 The Medical Challenge of Cartilage Injury Cartilage is an important connective tissue within human joints, with hyaline cartilage especially covering joint surfaces and playing a core role in smooth movem...

Generative Prediction of Causal Gene Sets Responsible for Complex Traits

Information Science, Artificial Intelligence, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
gene regulatory networks   complex traits   generative deep learning   variational autoencoder   causal gene sets   phenotypic variation   polygenic diseases  

Generative Deep Learning for Predicting Causal Gene Sets of Complex Traits: PNAS Landmark New Method Explained I. Academic Background and Research Motivation The Dilemma of Complex Traits The relationship between genotype and phenotype has long been one of the core issues in biology and genetics. This challenge is especially prominent in the study ...

Systematic Reconstruction of Molecular Pathway Signatures Using Scalable Single-Cell Perturbation Screens

Medicine, Life Sciences, Cell Biology, Bioengineering, Immunology, Genetics,
single-cell sequencing   gene regulatory networks   CRISPR interference   functional genomics   signaling pathways  

In the field of functional genomics, researchers have long been dedicated to predicting causal regulatory relationships from observational data. However, despite modern technologies enabling the measurement of diverse molecular modalities, inferring causal regulatory relationships from observational data remains challenging. In particular, the iden...