Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
muscle-derived miR-126   TDP-43 axonal synthesis   neuromuscular junction   ALS models   neurodegeneration   local protein synthesis  

Muscle-derived miR-126 Regulates Axonal Local Synthesis of TDP-43 to Maintain Neuromuscular Junction Integrity in ALS Models — Review of a Nature Neuroscience Article I. Academic Background and Research Motivation Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset motor neuron disease, primarily characterized by neuromuscular junction (NMJ)...