Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
muscle-derived miR-126   TDP-43 axonal synthesis   neuromuscular junction   ALS models   neurodegeneration   local protein synthesis  

Muscle-derived miR-126 Regulates Axonal Local Synthesis of TDP-43 to Maintain Neuromuscular Junction Integrity in ALS Models — Review of a Nature Neuroscience Article I. Academic Background and Research Motivation Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset motor neuron disease, primarily characterized by neuromuscular junction (NMJ)...

Inter-alpha-trypsin inhibitor heavy chain h3 is a potential biomarker for disease activity in myasthenia gravis

Information Science, Artificial Intelligence, Medicine, Medical Laboratory Science, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
myasthenia gravis   biomarker   inter-alpha-trypsin inhibitor heavy chain h3   muscle proteomics   neuromuscular junction   acetylcholine receptor  

Research Background Myasthenia Gravis (MG) is a chronic antibody-mediated autoimmune disease that primarily affects synaptic transmission at the neuromuscular junction. Approximately 85% of MG patients are antibody-mediated targeting acetylcholine receptors (AChR). The clinical features of this disease include muscle weakness, especially fatigue-in...